Soy isoflavone intake increases bone mineral density in the spine of menopausal women: Meta-analysis of randomized controlled trials
The effects of isoflavones on bone loss appear inconsistent in randomized controlled trials. Therefore, we used a statistical method of combining these diverse data to clarify the effects of soy isoflavone intake on spine bone loss. We identified randomized controlled trials related to the effects o...
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| Vydáno v: | Clinical nutrition (Edinburgh, Scotland) Ročník 27; číslo 1; s. 57 - 64 |
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| Hlavní autoři: | , , , |
| Médium: | Journal Article |
| Jazyk: | angličtina |
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Kidlington
Elsevier Ltd
01.02.2008
Elsevier |
| Témata: | |
| ISSN: | 0261-5614, 1532-1983, 1532-1983 |
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| Abstract | The effects of isoflavones on bone loss appear inconsistent in randomized controlled trials. Therefore, we used a statistical method of combining these diverse data to clarify the effects of soy isoflavone intake on spine bone loss.
We identified randomized controlled trials related to the effects of soy isoflavone intake on spine bone mineral density or spine bone mineral content and performed meta-analysis with Review Manager 4.2 software.
Ten studies with a total of 608 subjects were selected for meta-analysis. The spine bone mineral density in subjects who consumed isoflavones increased significantly by 20.6
mg/cm
2 (95% confidence interval: 4.5–36.6
mg/cm
2) in comparison to that in subjects who did not consume isoflavones. Isoflavone intake vs placebo intake increased spine bone mineral content by 0.93
g (95% confidence interval: −0.37 to 2.24
g) with borderline significance. Increases in the spine bone mineral density with isoflavone intake of more than 90
mg/day and with treatment lasting 6 months were 28.5
mg/cm
2 (95% confidence interval: 8.4–48.6
mg/cm
2) and 27
mg/cm
2 (95% confidence interval: 8.3–45.8
mg/cm
2), respectively.
Isoflavone intervention significantly attenuates bone loss of the spine in menopausal women. These favorable effects become more significant when more than 90
mg/day of isoflavones are consumed. And soy isoflavone consumption for 6 months can be enough to exert beneficial effects on bone in menopausal women. |
|---|---|
| AbstractList | The effects of isoflavones on bone loss appear inconsistent in randomized controlled trials. Therefore, we used a statistical method of combining these diverse data to clarify the effects of soy isoflavone intake on spine bone loss.
We identified randomized controlled trials related to the effects of soy isoflavone intake on spine bone mineral density or spine bone mineral content and performed meta-analysis with Review Manager 4.2 software.
Ten studies with a total of 608 subjects were selected for meta-analysis. The spine bone mineral density in subjects who consumed isoflavones increased significantly by 20.6
mg/cm
2 (95% confidence interval: 4.5–36.6
mg/cm
2) in comparison to that in subjects who did not consume isoflavones. Isoflavone intake vs placebo intake increased spine bone mineral content by 0.93
g (95% confidence interval: −0.37 to 2.24
g) with borderline significance. Increases in the spine bone mineral density with isoflavone intake of more than 90
mg/day and with treatment lasting 6 months were 28.5
mg/cm
2 (95% confidence interval: 8.4–48.6
mg/cm
2) and 27
mg/cm
2 (95% confidence interval: 8.3–45.8
mg/cm
2), respectively.
Isoflavone intervention significantly attenuates bone loss of the spine in menopausal women. These favorable effects become more significant when more than 90
mg/day of isoflavones are consumed. And soy isoflavone consumption for 6 months can be enough to exert beneficial effects on bone in menopausal women. The effects of isoflavones on bone loss appear inconsistent in randomized controlled trials. Therefore, we used a statistical method of combining these diverse data to clarify the effects of soy isoflavone intake on spine bone loss.BACKGROUND & AIMSThe effects of isoflavones on bone loss appear inconsistent in randomized controlled trials. Therefore, we used a statistical method of combining these diverse data to clarify the effects of soy isoflavone intake on spine bone loss.We identified randomized controlled trials related to the effects of soy isoflavone intake on spine bone mineral density or spine bone mineral content and performed meta-analysis with Review Manager 4.2 software.METHODSWe identified randomized controlled trials related to the effects of soy isoflavone intake on spine bone mineral density or spine bone mineral content and performed meta-analysis with Review Manager 4.2 software.Ten studies with a total of 608 subjects were selected for meta-analysis. The spine bone mineral density in subjects who consumed isoflavones increased significantly by 20.6 mg/cm(2) (95% confidence interval: 4.5-36.6 mg/cm(2)) in comparison to that in subjects who did not consume isoflavones. Isoflavone intake vs placebo intake increased spine bone mineral content by 0.93 g (95% confidence interval: -0.37 to 2.24 g) with borderline significance. Increases in the spine bone mineral density with isoflavone intake of more than 90 mg/day and with treatment lasting 6 months were 28.5mg/cm(2) (95% confidence interval: 8.4-48.6 mg/cm(2)) and 27 mg/cm(2) (95% confidence interval: 8.3-45.8 mg/cm(2)), respectively.RESULTSTen studies with a total of 608 subjects were selected for meta-analysis. The spine bone mineral density in subjects who consumed isoflavones increased significantly by 20.6 mg/cm(2) (95% confidence interval: 4.5-36.6 mg/cm(2)) in comparison to that in subjects who did not consume isoflavones. Isoflavone intake vs placebo intake increased spine bone mineral content by 0.93 g (95% confidence interval: -0.37 to 2.24 g) with borderline significance. Increases in the spine bone mineral density with isoflavone intake of more than 90 mg/day and with treatment lasting 6 months were 28.5mg/cm(2) (95% confidence interval: 8.4-48.6 mg/cm(2)) and 27 mg/cm(2) (95% confidence interval: 8.3-45.8 mg/cm(2)), respectively.Isoflavone intervention significantly attenuates bone loss of the spine in menopausal women. These favorable effects become more significant when more than 90 mg/day of isoflavones are consumed. And soy isoflavone consumption for 6 months can be enough to exert beneficial effects on bone in menopausal women.CONCLUSIONSIsoflavone intervention significantly attenuates bone loss of the spine in menopausal women. These favorable effects become more significant when more than 90 mg/day of isoflavones are consumed. And soy isoflavone consumption for 6 months can be enough to exert beneficial effects on bone in menopausal women. Background & aims: The effects of isoflavones on bone loss appear inconsistent in randomized controlled trials. Therefore, we used a statistical method of combining these diverse data to clarify the effects of soy isoflavone intake on spine bone loss. Methods: We identified randomized controlled trials related to the effects of soy isoflavone intake on spine bone mineral density or spine bone mineral content and performed meta-analysis with Review Manager 4.2 software. Results: Ten studies with a total of 608 subjects were selected for meta-analysis. The spine bone mineral density in subjects who consumed isoflavones increased significantly by 20.6 mg/cm super(2) (95% confidence interval: 4.5-36.6 mg/cm super(2)) in comparison to that in subjects who did not consume isoflavones. Isoflavone intake vs placebo intake increased spine bone mineral content by 0.93 g (95% confidence interval: -0.37 to 2.24g) with borderline significance. Increases in the spine bone mineral density with isoflavone intake of more than 90 mg/day and with treatment lasting 6 months were 28.5 mg/cm super(2) (95% confidence interval: 8.4-48.6 mg/cm super(2)) and 27mg/cm super(2) (95% confidence interval: 8.3-45.8 mg/cm super(2)), respectively. Conclusions: Isoflavone intervention significantly attenuates bone loss of the spine in menopausal women. These favorable effects become more significant when more than 90 mg/day of isoflavones are consumed. And soy isoflavone consumption for 6 months can be enough to exert beneficial effects on bone in menopausal women. Summary Background & aims The effects of isoflavones on bone loss appear inconsistent in randomized controlled trials. Therefore, we used a statistical method of combining these diverse data to clarify the effects of soy isoflavone intake on spine bone loss. Methods We identified randomized controlled trials related to the effects of soy isoflavone intake on spine bone mineral density or spine bone mineral content and performed meta-analysis with Review Manager 4.2 software. Results Ten studies with a total of 608 subjects were selected for meta-analysis. The spine bone mineral density in subjects who consumed isoflavones increased significantly by 20.6 mg/cm2 (95% confidence interval: 4.5–36.6 mg/cm2 ) in comparison to that in subjects who did not consume isoflavones. Isoflavone intake vs placebo intake increased spine bone mineral content by 0.93 g (95% confidence interval: −0.37 to 2.24 g) with borderline significance. Increases in the spine bone mineral density with isoflavone intake of more than 90 mg/day and with treatment lasting 6 months were 28.5 mg/cm2 (95% confidence interval: 8.4–48.6 mg/cm2 ) and 27 mg/cm2 (95% confidence interval: 8.3–45.8 mg/cm2 ), respectively. Conclusions Isoflavone intervention significantly attenuates bone loss of the spine in menopausal women. These favorable effects become more significant when more than 90 mg/day of isoflavones are consumed. And soy isoflavone consumption for 6 months can be enough to exert beneficial effects on bone in menopausal women. The effects of isoflavones on bone loss appear inconsistent in randomized controlled trials. Therefore, we used a statistical method of combining these diverse data to clarify the effects of soy isoflavone intake on spine bone loss. We identified randomized controlled trials related to the effects of soy isoflavone intake on spine bone mineral density or spine bone mineral content and performed meta-analysis with Review Manager 4.2 software. Ten studies with a total of 608 subjects were selected for meta-analysis. The spine bone mineral density in subjects who consumed isoflavones increased significantly by 20.6 mg/cm(2) (95% confidence interval: 4.5-36.6 mg/cm(2)) in comparison to that in subjects who did not consume isoflavones. Isoflavone intake vs placebo intake increased spine bone mineral content by 0.93 g (95% confidence interval: -0.37 to 2.24 g) with borderline significance. Increases in the spine bone mineral density with isoflavone intake of more than 90 mg/day and with treatment lasting 6 months were 28.5mg/cm(2) (95% confidence interval: 8.4-48.6 mg/cm(2)) and 27 mg/cm(2) (95% confidence interval: 8.3-45.8 mg/cm(2)), respectively. Isoflavone intervention significantly attenuates bone loss of the spine in menopausal women. These favorable effects become more significant when more than 90 mg/day of isoflavones are consumed. And soy isoflavone consumption for 6 months can be enough to exert beneficial effects on bone in menopausal women. |
| Author | Qin, Li-Qiang Wang, Pei-Yu Katoh, Ryohei Ma, De-Fu |
| Author_xml | – sequence: 1 givenname: De-Fu surname: Ma fullname: Ma, De-Fu organization: Department of Social Medicine & Health Education, School of Public Health, Peking University, Beijing 100083, PR China – sequence: 2 givenname: Li-Qiang surname: Qin fullname: Qin, Li-Qiang organization: Department of Nutrition & Food Hygiene, School of Radiation Medicine & Public Health, Soochow University, Suzhou 215123, PR China – sequence: 3 givenname: Pei-Yu surname: Wang fullname: Wang, Pei-Yu email: wpeiyu@hsc.pku.edu.cn organization: Department of Social Medicine & Health Education, School of Public Health, Peking University, Beijing 100083, PR China – sequence: 4 givenname: Ryohei surname: Katoh fullname: Katoh, Ryohei organization: Department of Human Pathology, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Yamanashi 409-3898, Japan |
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| Snippet | The effects of isoflavones on bone loss appear inconsistent in randomized controlled trials. Therefore, we used a statistical method of combining these diverse... Summary Background & aims The effects of isoflavones on bone loss appear inconsistent in randomized controlled trials. Therefore, we used a statistical method... Background & aims: The effects of isoflavones on bone loss appear inconsistent in randomized controlled trials. Therefore, we used a statistical method of... |
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| SubjectTerms | Biological and medical sciences Bone Density - drug effects Bone mineral content Bone mineral density Feeding. Feeding behavior Female Fundamental and applied biological sciences. Psychology Gastroenterology and Hepatology Glycine max - chemistry Humans Investigative techniques, diagnostic techniques (general aspects) Isoflavone Isoflavones - pharmacology Medical sciences Menopause Middle Aged Osteoarticular system. Muscles Osteoporosis Osteoporosis, Postmenopausal - drug therapy Radiodiagnosis. Nmr imagery. Nmr spectrometry Randomized Controlled Trials as Topic Time Factors Treatment Outcome Vertebrates: anatomy and physiology, studies on body, several organs or systems |
| Title | Soy isoflavone intake increases bone mineral density in the spine of menopausal women: Meta-analysis of randomized controlled trials |
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