Anti-thymoglobulin (ATG) treatment does not reverse type 1 diabetes in the acute virally induced rat insulin promoter-lymphocytic choriomeningitis virus (RIP-LCMV) model

Immune modulators such as anti-thymoglobulin (ATG) are under clinical evaluation for the treatment of type 1 diabetes (T1D). Although such agents have cured T1D in the non-obese diabetic (NOD) model, their clinical efficacy has been much lower. In order to improve the odds of successful translation...

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Bibliographic Details
Published in:	Clinical and experimental immunology Vol. 163; no. 3; pp. 375 - 380
Main Authors:	Bresson, D, von Herrath, M.G
Format:	Journal Article
Language:	English
Published:	Oxford, UK Blackwell Publishing Ltd 01.03.2011 Blackwell Oxford University Press Blackwell Science Inc
Subjects:	Analytical, structural and metabolic biochemistry Animal Models Animals Antibodies Antilymphocyte Serum - administration & dosage Antilymphocyte Serum - therapeutic use anti‐thymoglobulin autoimmunity Biological and medical sciences Blood Glucose - metabolism CD25 antigen CD4 antigen CD4-CD8 Ratio CD4-Positive T-Lymphocytes - immunology CD4-Positive T-Lymphocytes - pathology CD8 antigen CD8-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - pathology Clinical trials Data processing Diabetes Diabetes mellitus Diabetes Mellitus, Type 1 - blood Diabetes Mellitus, Type 1 - etiology Diabetes Mellitus, Type 1 - immunology Diabetes Mellitus, Type 1 - therapy Diabetes. Impaired glucose tolerance Disease Models, Animal Endocrine pancreas. Apud cells (diseases) Endocrinopathies Etiopathogenesis. Screening. Investigations. Target tissue resistance Fundamental and applied biological sciences. Psychology Immunomodulation Immunoregulation Infection Insulin Insulin - genetics Interleukin-2 Receptor alpha Subunit - metabolism Kinetics Lymphocyte Count Lymphocyte Depletion Lymphocytes T Lymphocytic choriomeningitis virus - genetics Lymphocytic choriomeningitis virus - isolation & purification Medical research Medical sciences Mice Mice, Inbred C57BL Mice, Transgenic Promoter Regions, Genetic - genetics Rats regulatory T cells RIP‐LCMV mice T-Lymphocyte Subsets - immunology T-Lymphocyte Subsets - metabolism T-Lymphocyte Subsets - pathology T-Lymphocytes, Regulatory - immunology T-Lymphocytes, Regulatory - metabolism T-Lymphocytes, Regulatory - pathology Translation Treatment Outcome type 1 diabetes Viral Load - immunology Endocrinopathy Autoimmunity Pancreatic hormone Rat Autoimmune disease Biochemistry Promoter T-Lymphocyte anti-thymoglobulin Antithymocyte globulin Regulatory cell RIP-LCMV mice Immunopathology Acute Rodentia Insulin Arenavirus Virus regulatory T cells Vertebrata Mammalia Treatment Lymphocytic choriomeningitis virus Mouse Type 1 diabetes Animal Reversibility Models Arenaviridae
ISSN:	0009-9104, 1365-2249, 1365-2249
Online Access:	Get full text
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