The role of monocytes in angiogenesis and atherosclerosis

New vessel formation inside the arterial wall and atherosclerotic plaques plays a critical role in pathogenesis of heart attacks and strokes. The 2 known mechanisms resulting in the formation of new vessels within the plaque are local ischemia and inflammation. Blood monocytes play an important role...

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Podrobná bibliografia
Vydané v:	Journal of the American College of Cardiology Ročník 63; číslo 1; s. 1
Hlavní autori:	Jaipersad, Anthony S, Lip, Gregory Y H, Silverman, Stanley, Shantsila, Eduard
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States 07.01.2014
Predmet:	Atherosclerosis - immunology Endothelium, Vascular - immunology Humans Immunity, Cellular Monocytes - physiology Neovascularization, Pathologic - immunology basic fibroblast growth factor hypoxia inducible factor tyrosine kinase beta adrenergic system TNF βA endothelial progenitor cells interleukin monocyte chemoattractant protein monocytes IL HIF ICAM Tie2 VEGF angiogenesis angiopoietin bFGF Tie VCAM vascular adhesion molecule tumor necrosis factor vascular endothelial growth factor EPC monocyte subsets Ang MCP intracellular adhesion molecule
ISSN:	1558-3597, 1558-3597
On-line prístup:	Zistit podrobnosti o prístupe
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Popis
Shrnutí:	New vessel formation inside the arterial wall and atherosclerotic plaques plays a critical role in pathogenesis of heart attacks and strokes. The 2 known mechanisms resulting in the formation of new vessels within the plaque are local ischemia and inflammation. Blood monocytes play an important role in both processes. First, they express receptors for vascular endothelial growth factor and some of them may serve as circulating ancestors of endothelial cells. Second, monocytes are associated with inflammation by synthesis of inflammatory molecules following their activation (e.g., after stimulation of Toll-like receptors). Neovascularization is a reparative response to ischemia, and includes 3 processes: angiogenesis, arteriogenesis, and vasculogenesis. Angiogenesis, the formation of new capillary vessels is known to occur in response to a hypoxic environment. The interaction between leukocytes and vascular wall via overexpression of various molecules facilitates the migration of inflammatory cells into the plaque microenvironment. Monocytes are intimately involved in tissue damage and repair and an imbalance of these processes may have detrimental consequences for plaque development and stability. Importantly, monocytes are comprised of distinct subsets with different cell surface markers and functional characteristics and this heterogeneity may be relevant to angiogenic processes in atherosclerosis. The aim of this review article is to present an overview of the available evidence supporting a role for monocytes in angiogenesis and atherosclerosis.
Bibliografia:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 ObjectType-Review-3 content type line 23
ISSN:	1558-3597 1558-3597
DOI:	10.1016/j.jacc.2013.09.019