Persistent viremia and urine shedding of tick-borne encephalitis virus in an infected immunosuppressed patient from a new epidemic cluster in North-Eastern Italy

[Display omitted] •A rare case of persistent TBEV infection of an immune-suppressed patient.•Virus detection in the erythrocyte fraction is observed for the first time with TBEV.•Shedding of TBEV in the urine lasted for over two months.•Identification of a cluster of three TBEV infected patients in...

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Veröffentlicht in:Journal of Clinical Virology Jg. 69; S. 48 - 51
Hauptverfasser: Caracciolo, Ilaria, Bassetti, Matteo, Paladini, Giorgio, Luzzati, Roberto, Santon, Daniela, Merelli, Maria, Sabbata, Giovanni De, Carletti, Tea, Marcello, Alessandro, D’Agaro, Pierlanfranco
Format: Journal Article
Sprache:Englisch
Veröffentlicht: Netherlands Elsevier B.V 01.08.2015
Elsevier BV
Schlagworte:
Aged
Allergy and Immunology
Antibodies, Viral
Antibodies, Viral - blood
Antineoplastic Agents
Antineoplastic Agents - administration & dosage
Antineoplastic Agents - immunology
Encephalitis Viruses, Tick-Borne
Encephalitis Viruses, Tick-Borne - genetics
Encephalitis Viruses, Tick-Borne - immunology
Encephalitis Viruses, Tick-Borne - isolation & purification
Encephalitis Viruses, Tick-Borne - physiology
Encephalitis, Tick-Borne
Encephalitis, Tick-Borne - diagnosis
Encephalitis, Tick-Borne - epidemiology
Encephalitis, Tick-Borne - virology
Epidemics
Flaviviridae
Friuli-Venezia Giulia region
Friuli-Venezia Giulia region; Immuno-compromized host; Italy; Persistent infection; Real-time PCR; Sequencing; TBEV; Tick-borne encephalitis; Trieste; Virus isolation
Friuli-Venezia Giulia region; Immuno-compromized host; Italy; Persistent infection; Real-time PCR; Sequencing; TBEV; Tick-borne encephalitis; Trieste; Virus isolation; Aged; Antibodies, Viral; Antineoplastic Agents; Encephalitis Viruses, Tick-Borne; Encephalitis, Tick-Borne; Epidemics; Humans; Italy; Male; Real-Time Polymerase Chain Reaction; Urine; Viremia; Immunocompromised Host; Virus Shedding
Friuli-Venezia Giulia region; Immuno-compromized host; Italy; Persistent infection; Real-time PCR; Sequencing; TBEV; Tick-borne encephalitis; Trieste; Virus isolation; Aged; Antibodies, Viral; Antineoplastic Agents; Encephalitis Viruses, Tick-Borne; Encephalitis, Tick-Borne; Epidemics; Humans; Italy; Male; Real-Time Polymerase Chain Reaction; Urine; Viremia; Immunocompromised Host; Virus Shedding; Virology; Infectious Diseases; Medicine (all)
Humans
Immuno-compromized host
Immunocompromised Host
Infectious Disease
Italy
Italy - epidemiology
Male
Persistent infection
Real-time PCR
Real-Time Polymerase Chain Reaction
Sequencing
TBEV
Tick-borne encephaliti
Tick-borne encephalitis
Tick-borne encephalitis virus
Trieste
Urine
Urine - virology
Viremia
Viremia - virology
Virus isolation
Virus Shedding
Italy
Trieste
Tick-borne encephalitis
Virus isolation
3’NCR
NS5
Immuno-compromized host
Friuli-Venezia Giulia region
Real-time PCR
FVG
Persistent infection
TBEV
Italy
Sequencing
Friuli Venezia Giulia
3’non-coding region
non-structural protein 5
tick-borne encephalitis virus
ISSN:1386-6532, 1873-5967, 1873-5967
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Zusammenfassung:[Display omitted] •A rare case of persistent TBEV infection of an immune-suppressed patient.•Virus detection in the erythrocyte fraction is observed for the first time with TBEV.•Shedding of TBEV in the urine lasted for over two months.•Identification of a cluster of three TBEV infected patients in a new area of North-Eastern Italy. A persistent tick-borne encephalitis virus infection in an immune-suppressed patient is presented. Such an unusual clinical case offers the unique chance of detecting persistent viremia associated to the erythrocyte fraction and shedding of the virus in the urine for more than six weeks. The infection occurred in a new area of the Friuli Venezia-Giulia region (North Eastern Italy) where two additional cases are also being reported.
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ObjectType-Feature-4
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ISSN:1386-6532
1873-5967
1873-5967
DOI:10.1016/j.jcv.2015.05.019