Standardizing double-blind, placebo-controlled oral food challenges: American Academy of Allergy, Asthma & Immunology–European Academy of Allergy and Clinical Immunology PRACTALL consensus report

In an article reviewing the status of gastrointestinal allergy in the New England Journal of Medicine in 1949, Ingelfinger etÂ al1 decried the reliance on patients' "incrimination" of specific foods, outcome of trial diets, or association of abdominal complaints with symptoms believed...

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Veröffentlicht in:	Journal of allergy and clinical immunology Jg. 130; H. 6; S. 1260 - 1274
Hauptverfasser:	Sampson, Hugh A., Gerth van Wijk, Roy, Bindslev-Jensen, Carsten, Sicherer, Scott, Teuber, Suzanne S., Burks, A. Wesley, Dubois, Anthony E.J., Beyer, Kirsten, Eigenmann, Philippe A., Spergel, Jonathan M., Werfel, Thomas, Chinchilli, Vernon M.
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	New York, NY Mosby, Inc 01.12.2012 Elsevier Elsevier Limited
Schlagworte:	Allergens - immunology Allergic diseases Allergies Allergy and Immunology Allergy and Immunology - trends Biological and medical sciences Biomedical Research - standards Chronic obstructive pulmonary disease, asthma Digestive allergic diseases double-blind Double-Blind Method Eczema - diagnosis Eczema - immunology Europe Food Food - adverse effects Food allergies Food allergy Food Hypersensitivity - diagnosis Food Hypersensitivity - immunology Fundamental and applied biological sciences. Psychology Fundamental immunology Humans Immunoglobulin E - immunology Immunologic Tests - methods Immunologic Tests - standards Immunopathology Medical sciences Milk oral food challenge Patients placebo-controlled food challenge Placebos Pneumology Proteins Randomized Controlled Trials as Topic - standards Research Design - standards Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis Skin Tests - methods Skin Tests - standards Studies United States United States North America Europe America Food allergy NO AD APT oral food challenge OFC placebo-controlled food challenge LOAEL SPT NOAEL double-blind DBPCFC ML Double-blind, placebo-controlled food challenge Skin prick test No observable adverse event level Atopic dermatitis Nitric oxide Atopy patch test Maximum likelihood Lowest observable adverse event level Lung disease Immunopathology Respiratory disease Consensus Asthma Immunology Placebo Digestive diseases Bronchus disease Obstructive pulmonary disease Provocation test
ISSN:	0091-6749, 1097-6825, 1097-6825
Online-Zugang:	Volltext
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Zusammenfassung:	In an article reviewing the status of gastrointestinal allergy in the New England Journal of Medicine in 1949, Ingelfinger etÂ al1 decried the reliance on patients' "incrimination" of specific foods, outcome of trial diets, or association of abdominal complaints with symptoms believed to be allergic in making the diagnosis of food allergy. Recently, the National Institutes of Health-sponsored expert panel "Guidelines for the diagnosis and management of food allergy," reaffirmed the utility of the DBPCFC for diagnosing food allergy after an extensive review of the current literature.11 However, the expert panel noted that open or single-blind challenges could also be acceptable when the challenge outcome is negative or when objective symptoms are elicited that exactly recapitulate the history of the reaction.
Bibliographie:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 ObjectType-News-1 ObjectType-Feature-4 ObjectType-Conference-2 content type line 23 ObjectType-Article-3
ISSN:	0091-6749 1097-6825 1097-6825
DOI:	10.1016/j.jaci.2012.10.017