Prevalence and Risk Factors for COPD at High Altitude: A Large Cross-Sectional Survey of Subjects Living Between 2,100–4,700 m Above Sea Level

Aim of Study: Four hundred million people live at high altitude worldwide. Prevalence and risk factors for COPD in these populations are poorly documented. We examined the prevalence and risk factors for COPD in residents living at an altitude of 2,100–4,700 m. Methods: We performed a cross-sectiona...

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Published in:Frontiers in Medicine Vol. 7; p. 581763
Main Authors: Guo, Yanfei, Xing, Zhenzhen, Shan, Guangliang, Janssens, Jean-Paul, Sun, Tieying, Chai, Di, Liu, Weiming, Wang, Yuxia, Ma, Yali, Tong, Yaqi, Huang, Yilin, Cao, Yang, Wang, Chen
Format: Journal Article
Language:English
Published: Switzerland Frontiers Media SA 03.12.2020
Frontiers Media S.A
Subjects:
Age groups
Air pollution
Altitude
Bronchodilators
Chronic obstructive pulmonary disease
Chronic Obstructive Pulmonary Disease (COPD)
Data collection
Females
high altitude
household air pollution
Households
Humidity
Indoor air quality
info:eu-repo/classification/ddc/616
Medicine
Medicine (General)
Population
prevalence
R5-920
Risk factors
Sea level
Smoking
Spirometry
Tuberculosis
Variance analysis
China
prevalence
high altitude
risk factors
household air pollution
Chronic Obstructive Pulmonary Disease (COPD)
tuberculosis
ISSN:2296-858X, 2296-858X
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Summary:Aim of Study: Four hundred million people live at high altitude worldwide. Prevalence and risk factors for COPD in these populations are poorly documented. We examined the prevalence and risk factors for COPD in residents living at an altitude of 2,100–4,700 m. Methods: We performed a cross-sectional survey in Xinjiang and Tibet autonomous region. A multistage stratified sampling procedure was used to select a representative population aged 15 years or older from eight high altitude regions. All participants underwent pre- and post-bronchodilator measurement of forced expiratory volumes. COPD was diagnosed according to 2019 Global Initiative for Chronic Obstructive Lung Disease (GOLD) criteria. Results: Between June, 2015 and August 2016, 4,967 subjects were included. Median age was 38.0 years (range: 15–91 years; inter-quartile range: 28–49 years); 51.4% participants were female. Overall prevalence of spirometry-defined COPD was 8.2% (95% CI 7.4–8.9%): 9.3% in male (95% CI 8.2–10.4%), and 7.1% in female (95% CI 6.1–8.2%). By multivariable logistic regression analysis, COPD was significantly associated with being aged ≥40 years (odds ratio: 2.25 [95% CI 1.72–2.95], P < 0.0001), exposure to household air pollution (OR: 1.34 [95% CI 1.01–1.79], P = 0.043), and a history of tuberculosis (OR: 1.79 [95% CI 1.23–2.61], P = 0.030), while living at a higher altitude (OR: 0.45 [95% CI 0.33–0.61], P < 0.0001) and having a higher educational level (OR: 0.64 [95% CI 0.43–0.95], P = 0.025) were associated with a lower prevalence of COPD. Conclusions: Our results show that the spirometry-defined COPD is a considerable health problem for residents living at high altitudes and COPD prevalence was inversely correlated with altitude. Preventing exposure to household air pollution and reducing the incidence of tuberculosis should be public health priorities for high altitude residents.
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Reviewed by: Denis Vinnikov, Al-Farabi Kazakh National University, Kazakhstan; Michael Furian, University Hospital Zurich, Switzerland
Edited by: Konrad E. Bloch, University Hospital Zürich, Switzerland
These authors have contributed equally to this work
This article was submitted to Pulmonary Medicine, a section of the journal Frontiers in Medicine
ISSN:2296-858X
2296-858X
DOI:10.3389/fmed.2020.581763