Reduced telomerase activity in human T lymphocytes exposed to cortisol

Accelerated telomere shortening in lymphocytes has been associated with a variety of human pathologies, including HIV disease, Down syndrome, and cardiovascular disease. Recent findings indicate that reduced telomere length is also associated with chronic psychological stress and mood disorders. Tel...

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Bibliographic Details
Published in:	Brain, behavior, and immunity Vol. 22; no. 4; pp. 600 - 605
Main Authors:	Choi, Jenny, Fauce, Steven R., Effros, Rita B.
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier Inc 01.05.2008
Subjects:	Adult Allergy and Immunology Anti-Inflammatory Agents - pharmacology CD4-Positive T-Lymphocytes - drug effects CD4-Positive T-Lymphocytes - enzymology CD8-Positive T-Lymphocytes - drug effects CD8-Positive T-Lymphocytes - enzymology Cells, Cultured Cortisol Enzyme Activation - drug effects Enzyme Activation - immunology Female Human Human immunodeficiency virus Humans Hydrocortisone - pharmacology Male Middle Aged Protein Subunits - genetics Protein Subunits - metabolism Psychiatry RNA, Messenger - metabolism Stress T lymphocytes Telomerase Telomerase - genetics Telomerase - metabolism Telomeres T lymphocytes Human Telomeres Cortisol Telomerase Stress
ISSN:	0889-1591, 1090-2139, 1090-2139
Online Access:	Get full text
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