Detection of SARS-CoV-2-Specific Humoral and Cellular Immunity in COVID-19 Convalescent Individuals

The World Health Organization has declared SARS-CoV-2 virus outbreak a worldwide pandemic. However, there is very limited understanding on the immune responses, especially adaptive immune responses to SARS-CoV-2 infection. Here, we collected blood from COVID-19 patients who have recently become viru...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Immunity (Cambridge, Mass.) Ročník 52; číslo 6; s. 971
Hlavní autoři: Ni, Ling, Ye, Fang, Cheng, Meng-Li, Feng, Yu, Deng, Yong-Qiang, Zhao, Hui, Wei, Peng, Ge, Jiwan, Gou, Mengting, Li, Xiaoli, Sun, Lin, Cao, Tianshu, Wang, Pengzhi, Zhou, Chao, Zhang, Rongrong, Liang, Peng, Guo, Han, Wang, Xinquan, Qin, Cheng-Feng, Chen, Fang, Dong, Chen
Médium: Journal Article
Jazyk:angličtina
Vydáno: United States 16.06.2020
Témata:
Adult
Antibodies, Neutralizing - immunology
Antibodies, Viral - blood
Antibodies, Viral - immunology
Betacoronavirus - physiology
Convalescence
Coronavirus Infections - blood
Coronavirus Infections - immunology
Coronavirus Infections - pathology
COVID-19
Female
Humans
Immunity, Cellular
Immunity, Humoral
Male
Middle Aged
Pandemics
Pneumonia, Viral - blood
Pneumonia, Viral - immunology
Pneumonia, Viral - pathology
SARS-CoV-2
Spike Glycoprotein, Coronavirus - immunology
COVID-19 patients
SARS-CoV-2
SARS-CoV-2-specific antibody
adaptive immunity
SARS-CoV-2-specific T cells
ISSN:1097-4180, 1097-4180
On-line přístup:Zjistit podrobnosti o přístupu
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!
Popis
Shrnutí:The World Health Organization has declared SARS-CoV-2 virus outbreak a worldwide pandemic. However, there is very limited understanding on the immune responses, especially adaptive immune responses to SARS-CoV-2 infection. Here, we collected blood from COVID-19 patients who have recently become virus-free, and therefore were discharged, and detected SARS-CoV-2-specific humoral and cellular immunity in eight newly discharged patients. Follow-up analysis on another cohort of six patients 2 weeks post discharge also revealed high titers of immunoglobulin G (IgG) antibodies. In all 14 patients tested, 13 displayed serum-neutralizing activities in a pseudotype entry assay. Notably, there was a strong correlation between neutralization antibody titers and the numbers of virus-specific T cells. Our work provides a basis for further analysis of protective immunity to SARS-CoV-2, and understanding the pathogenesis of COVID-19, especially in the severe cases. It also has implications in developing an effective vaccine to SARS-CoV-2 infection.
Bibliografie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1097-4180
1097-4180
DOI:10.1016/j.immuni.2020.04.023