Relationship between MRI perfusion and clinical severity in multiple sclerosis

Perfusion alterations within several brain regions have been shown in multiple sclerosis patients using different magnetic resonance imaging (MRI) techniques. Furthermore, MRI-derived brain perfusion metrics have been investigated in association with multiple sclerosis phenotypes, physical disabilit...

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Veröffentlicht in:Neural regeneration research Jg. 15; H. 4; S. 646 - 652
Hauptverfasser: Lagana, Maria, Pelizzari, Laura, Baglio, Francesca
Format: Journal Article
Sprache:Englisch
Veröffentlicht: India Wolters Kluwer India Pvt. Ltd 01.04.2020
Medknow Publications & Media Pvt. Ltd
IRCCS, Fondazione Don Carlo Gnocchi, Milan, Italy
Wolters Kluwer - Medknow
Wolters Kluwer Medknow Publications
Schlagworte:
Atrophy
Blood
brain perfusion; cerebral blood flow; cognition; disability; magnetic resonance imaging; mri; multiple sclerosis; phenotypes; progressive; relapsing remitting
Cognition & reasoning
Disease
Magnetic resonance imaging
Multiple sclerosis
Review
Studies
magnetic resonance imaging
phenotypes
cognition
relapsing remitting
MRI
disability
multiple sclerosis
cerebral blood flow
progressive
brain perfusion
ISSN:1673-5374, 1876-7958
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Zusammenfassung:Perfusion alterations within several brain regions have been shown in multiple sclerosis patients using different magnetic resonance imaging (MRI) techniques. Furthermore, MRI-derived brain perfusion metrics have been investigated in association with multiple sclerosis phenotypes, physical disability, and cognitive impairment. However, a review focused on these aspects is still missing. Our aim was to review all the studies investigating the relationship between perfusion MRI and clinical severity during the last fifteen years to understand the clinical relevance of these findings. Perfusion differences among phenotypes were observed both with 1.5T and 3T scanners, with progressive multiple sclerosis presenting with lower perfusion values than relapsing-remitting multiple sclerosis patients. However, only 3T scanners showed a statistically significant distinction. Controversial results about the association between MRI-derived perfusion metrics and physical disability scores were found. However, the majority of the studies showed that lower brain perfusion and longer transit time are associated with more severe physical disability and worse cognitive performances.
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Author contributions: Conception and design of the manuscript: MML, LP, FB; manuscript writing: MML, LP; content review: MML, LP, FB.
ISSN:1673-5374
1876-7958
DOI:10.4103/1673-5374.266906