Cell death pathways: intricate connections and disease implications

Various forms of cell death have been identified over the last decades with each relying on a different subset of proteins for the activation and execution of their respective pathway(s). In addition to the three best characterized pathways—apoptosis, necroptosis, and pyroptosis—other forms of regul...

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Vydáno v:The EMBO journal Ročník 40; číslo 5; s. e106700 - n/a
Hlavní autoři: Kist, Matthias, Vucic, Domagoj
Médium: Journal Article
Jazyk:angličtina
Vydáno: London Nature Publishing Group UK 01.03.2021
Springer Nature B.V
John Wiley and Sons Inc
Témata:
Apoptosis
Autophagy
caspase
Cell Death
Disease - etiology
EMBO07
EMBO37
Ferroptosis
Homeostasis
Humans
Membrane permeability
Mitochondrial permeability transition pore
Mortality
Necroptosis
Necrosis
Phagocytosis
Pyroptosis
Reagents
Regulators
Review
RIPK1
Signal Transduction
Signaling
pyroptosis
apoptosis
RIPK1
caspase
necroptosis
ISSN:0261-4189, 1460-2075, 1460-2075
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Abstract Various forms of cell death have been identified over the last decades with each relying on a different subset of proteins for the activation and execution of their respective pathway(s). In addition to the three best characterized pathways—apoptosis, necroptosis, and pyroptosis—other forms of regulated cell death including autophagy‐dependent cell death (ADCD), mitochondrial permeability transition pore (MPTP)‐mediated necrosis, parthanatos, NETosis and ferroptosis, and their relevance for organismal homeostasis are becoming better understood. Importantly, it is increasingly clear that none of these pathways operate alone. Instead, a more complex picture is emerging with many pathways sharing components and signaling principles. Finally, a number of cell death regulators are implicated in human diseases and represent attractive therapeutic targets. Therefore, better understanding of physiological and mechanistic aspects of cell death signaling should yield improved reagents for addressing unmet medical needs. Graphical Abstract This review provides an overview of the different forms of cell death and how they are related to each other, as well as the role of cell death regulators in several pathophysiological processes.
AbstractList Various forms of cell death have been identified over the last decades with each relying on a different subset of proteins for the activation and execution of their respective pathway(s). In addition to the three best characterized pathways-apoptosis, necroptosis, and pyroptosis-other forms of regulated cell death including autophagy-dependent cell death (ADCD), mitochondrial permeability transition pore (MPTP)-mediated necrosis, parthanatos, NETosis and ferroptosis, and their relevance for organismal homeostasis are becoming better understood. Importantly, it is increasingly clear that none of these pathways operate alone. Instead, a more complex picture is emerging with many pathways sharing components and signaling principles. Finally, a number of cell death regulators are implicated in human diseases and represent attractive therapeutic targets. Therefore, better understanding of physiological and mechanistic aspects of cell death signaling should yield improved reagents for addressing unmet medical needs.Various forms of cell death have been identified over the last decades with each relying on a different subset of proteins for the activation and execution of their respective pathway(s). In addition to the three best characterized pathways-apoptosis, necroptosis, and pyroptosis-other forms of regulated cell death including autophagy-dependent cell death (ADCD), mitochondrial permeability transition pore (MPTP)-mediated necrosis, parthanatos, NETosis and ferroptosis, and their relevance for organismal homeostasis are becoming better understood. Importantly, it is increasingly clear that none of these pathways operate alone. Instead, a more complex picture is emerging with many pathways sharing components and signaling principles. Finally, a number of cell death regulators are implicated in human diseases and represent attractive therapeutic targets. Therefore, better understanding of physiological and mechanistic aspects of cell death signaling should yield improved reagents for addressing unmet medical needs.
Various forms of cell death have been identified over the last decades with each relying on a different subset of proteins for the activation and execution of their respective pathway(s). In addition to the three best characterized pathways—apoptosis, necroptosis, and pyroptosis—other forms of regulated cell death including autophagy‐dependent cell death (ADCD), mitochondrial permeability transition pore (MPTP)‐mediated necrosis, parthanatos, NETosis and ferroptosis, and their relevance for organismal homeostasis are becoming better understood. Importantly, it is increasingly clear that none of these pathways operate alone. Instead, a more complex picture is emerging with many pathways sharing components and signaling principles. Finally, a number of cell death regulators are implicated in human diseases and represent attractive therapeutic targets. Therefore, better understanding of physiological and mechanistic aspects of cell death signaling should yield improved reagents for addressing unmet medical needs. This review provides an overview of the different forms of cell death and how they are related to each other, as well as the role of cell death regulators in several pathophysiological processes.
Various forms of cell death have been identified over the last decades with each relying on a different subset of proteins for the activation and execution of their respective pathway(s). In addition to the three best characterized pathways-apoptosis, necroptosis, and pyroptosis-other forms of regulated cell death including autophagy-dependent cell death (ADCD), mitochondrial permeability transition pore (MPTP)-mediated necrosis, parthanatos, NETosis and ferroptosis, and their relevance for organismal homeostasis are becoming better understood. Importantly, it is increasingly clear that none of these pathways operate alone. Instead, a more complex picture is emerging with many pathways sharing components and signaling principles. Finally, a number of cell death regulators are implicated in human diseases and represent attractive therapeutic targets. Therefore, better understanding of physiological and mechanistic aspects of cell death signaling should yield improved reagents for addressing unmet medical needs.
Various forms of cell death have been identified over the last decades with each relying on a different subset of proteins for the activation and execution of their respective pathway(s). In addition to the three best characterized pathways—apoptosis, necroptosis, and pyroptosis—other forms of regulated cell death including autophagy‐dependent cell death (ADCD), mitochondrial permeability transition pore (MPTP)‐mediated necrosis, parthanatos, NETosis and ferroptosis, and their relevance for organismal homeostasis are becoming better understood. Importantly, it is increasingly clear that none of these pathways operate alone. Instead, a more complex picture is emerging with many pathways sharing components and signaling principles. Finally, a number of cell death regulators are implicated in human diseases and represent attractive therapeutic targets. Therefore, better understanding of physiological and mechanistic aspects of cell death signaling should yield improved reagents for addressing unmet medical needs. This review provides an overview of the different forms of cell death and how they are related to each other, as well as the role of cell death regulators in several pathophysiological processes.
Various forms of cell death have been identified over the last decades with each relying on a different subset of proteins for the activation and execution of their respective pathway(s). In addition to the three best characterized pathways—apoptosis, necroptosis, and pyroptosis—other forms of regulated cell death including autophagy‐dependent cell death (ADCD), mitochondrial permeability transition pore (MPTP)‐mediated necrosis, parthanatos, NETosis and ferroptosis, and their relevance for organismal homeostasis are becoming better understood. Importantly, it is increasingly clear that none of these pathways operate alone. Instead, a more complex picture is emerging with many pathways sharing components and signaling principles. Finally, a number of cell death regulators are implicated in human diseases and represent attractive therapeutic targets. Therefore, better understanding of physiological and mechanistic aspects of cell death signaling should yield improved reagents for addressing unmet medical needs. Graphical Abstract This review provides an overview of the different forms of cell death and how they are related to each other, as well as the role of cell death regulators in several pathophysiological processes.
Author Kist, Matthias
Vucic, Domagoj
AuthorAffiliation 1 Department of Early Discovery Biochemistry Genentech South San Francisco USA
AuthorAffiliation_xml – name: 1 Department of Early Discovery Biochemistry Genentech South San Francisco USA
Author_xml – sequence: 1
  givenname: Matthias
  surname: Kist
  fullname: Kist, Matthias
  organization: Department of Early Discovery Biochemistry, Genentech
– sequence: 2
  givenname: Domagoj
  orcidid: 0000-0003-3614-8093
  surname: Vucic
  fullname: Vucic, Domagoj
  email: domagoj@gene.com
  organization: Department of Early Discovery Biochemistry, Genentech
BackLink https://www.ncbi.nlm.nih.gov/pubmed/33439509$$D View this record in MEDLINE/PubMed
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Snippet Various forms of cell death have been identified over the last decades with each relying on a different subset of proteins for the activation and execution of...
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SubjectTerms Apoptosis
Autophagy
caspase
Cell Death
Disease - etiology
EMBO07
EMBO37
Ferroptosis
Homeostasis
Humans
Membrane permeability
Mitochondrial permeability transition pore
Mortality
Necroptosis
Necrosis
Phagocytosis
Pyroptosis
Reagents
Regulators
Review
RIPK1
Signal Transduction
Signaling
Title Cell death pathways: intricate connections and disease implications
URI https://link.springer.com/article/10.15252/embj.2020106700
https://onlinelibrary.wiley.com/doi/abs/10.15252%2Fembj.2020106700
https://www.ncbi.nlm.nih.gov/pubmed/33439509
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https://pubmed.ncbi.nlm.nih.gov/PMC7917554
Volume 40
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