Cell death pathways: intricate connections and disease implications

Various forms of cell death have been identified over the last decades with each relying on a different subset of proteins for the activation and execution of their respective pathway(s). In addition to the three best characterized pathways—apoptosis, necroptosis, and pyroptosis—other forms of regul...

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Veröffentlicht in:The EMBO journal Jg. 40; H. 5; S. e106700 - n/a
Hauptverfasser: Kist, Matthias, Vucic, Domagoj
Format: Journal Article
Sprache:Englisch
Veröffentlicht: London Nature Publishing Group UK 01.03.2021
Springer Nature B.V
John Wiley and Sons Inc
Schlagworte:
Apoptosis
Autophagy
caspase
Cell Death
Disease - etiology
EMBO07
EMBO37
Ferroptosis
Homeostasis
Humans
Membrane permeability
Mitochondrial permeability transition pore
Mortality
Necroptosis
Necrosis
Phagocytosis
Pyroptosis
Reagents
Regulators
Review
RIPK1
Signal Transduction
Signaling
pyroptosis
apoptosis
RIPK1
caspase
necroptosis
ISSN:0261-4189, 1460-2075, 1460-2075
Online-Zugang:Volltext
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Zusammenfassung:Various forms of cell death have been identified over the last decades with each relying on a different subset of proteins for the activation and execution of their respective pathway(s). In addition to the three best characterized pathways—apoptosis, necroptosis, and pyroptosis—other forms of regulated cell death including autophagy‐dependent cell death (ADCD), mitochondrial permeability transition pore (MPTP)‐mediated necrosis, parthanatos, NETosis and ferroptosis, and their relevance for organismal homeostasis are becoming better understood. Importantly, it is increasingly clear that none of these pathways operate alone. Instead, a more complex picture is emerging with many pathways sharing components and signaling principles. Finally, a number of cell death regulators are implicated in human diseases and represent attractive therapeutic targets. Therefore, better understanding of physiological and mechanistic aspects of cell death signaling should yield improved reagents for addressing unmet medical needs. Graphical Abstract This review provides an overview of the different forms of cell death and how they are related to each other, as well as the role of cell death regulators in several pathophysiological processes.
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ISSN:0261-4189
1460-2075
1460-2075
DOI:10.15252/embj.2020106700