Gut microbiota mediated the therapeutic efficacies and the side effects of prednisone in the treatment of MRL/lpr mice

Background Growing evidences indicate that the alterations in gut microbiota are associated with the efficacy of glucocorticoids (GCs) in the treatment of systemic lupus erythematosus (SLE). However, there is no evidence to prove whether gut microbiota directly mediates the effects of GCs. Methods U...

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Published in:Arthritis research & therapy Vol. 23; no. 1; pp. 1 - 10
Main Authors: Wang, Mingzhu, Zhu, Zhengyang, Lin, Xiaoying, Li, Haichang, Wen, Chengping, Bao, Jie, He, Zhixing
Format: Journal Article
Language:English
Published: London BioMed Central 14.09.2021
BioMed Central Ltd
Springer Nature B.V
BMC
Subjects:
Antibodies
Arthritis
Care and treatment
Corticosteroids
Disease
Dosage and administration
Drug dosages
Fecal microbiota transplantation
Feces
Gut microbiota
Health aspects
Immunosuppressive agents
Laboratory animals
Liver
Lupus
Medical research
Medicine
Medicine & Public Health
Microbiota
Microbiota (Symbiotic organisms)
MRL/lpr mice
Orthopedics
Prednisone
Research Article
Rheumatology
Spleen
Systemic lupus erythematosus
Testing
Tumor necrosis factor-TNF
China
Japan
Gut microbiota
Prednisone
Systemic lupus erythematosus
MRL/lpr mice
Fecal microbiota transplantation
ISSN:1478-6362, 1478-6354, 1478-6362
Online Access:Get full text
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Summary:Background Growing evidences indicate that the alterations in gut microbiota are associated with the efficacy of glucocorticoids (GCs) in the treatment of systemic lupus erythematosus (SLE). However, there is no evidence to prove whether gut microbiota directly mediates the effects of GCs. Methods Using the MRL/lpr mice, this study firstly addressed the effects of three doses of prednisone on gut microbiota. Then, this study used fecal microbiota transplantation (FMT) to transfer the gut microbiota of prednisone-treated MRL/lpr mice into the blank MRL/lpr mice to reveal whether the gut microbiota regulated by prednisone had similar therapeutic efficiency and side effects as prednisone. Results The effects of prednisone on gut microbiota were dose-dependent in the treatment of MRL/lpr mice. After transplantation into MRL/lpr mice, prednisone-regulated gut microbiota could alleviate lupus, which might be due to decreasing Ruminococcus and Alistipes and retaining the abundance of Lactobacillus . However, prednisone-regulated gut microbiota did not exhibit side effects as prednisone. The reason might be that the pathogens upregulated by prednisone could not survive in the MRL/lpr mice as exogenous microbiota, such as Parasutterella , Parabacteroides , and Escherichia-Shigella . Conclusions These data demonstrated that the transplantation of gut microbiota may be an effective method to obtain the therapeutic effects of GCs and avoid the side effects of GCs.
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ISSN:1478-6362
1478-6354
1478-6362
DOI:10.1186/s13075-021-02620-w