Antimicrobial peptides: mechanism of action, activity and clinical potential

The management of bacterial infections is becoming a major clinical challenge due to the rapid evolution of antibiotic resistant bacteria. As an excellent candidate to overcome antibiotic resistance, antimicrobial peptides (AMPs) that are produced from the synthetic and natural sources demonstrate a...

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Bibliographic Details
Published in:Military medical research Vol. 8; no. 1; pp. 1 - 25
Main Authors: Zhang, Qi-Yu, Yan, Zhi-Bin, Meng, Yue-Ming, Hong, Xiang-Yu, Shao, Gang, Ma, Jun-Jie, Cheng, Xu-Rui, Liu, Jun, Kang, Jian, Fu, Cai-Yun
Format: Journal Article
Language:English
Published: London BioMed Central 09.09.2021
Springer Nature B.V
BMC
Subjects:
Antibiotics
Antimicrobial agents
Antimicrobial peptides
Antimicrobial resistance
Bacteria
Bacterial infections
Biological activity
Birds
Bone marrow
Cancer therapies
Chemical bonds
Clinical application
Cytotoxicity
Drug resistance
Emergency Medicine
Fungi
Gram-negative bacteria
Gram-positive bacteria
Immune system
Infections
Insects
Invertebrates
Mechanism of action
Medicine
Medicine & Public Health
Microorganisms
Neutrophils
Pathogens
Peptides
Reptiles & amphibians
Review
Skin
Wound healing
Antimicrobial resistance
Mechanism of action
Clinical application
Biological activity
Antimicrobial peptides
ISSN:2054-9369, 2095-7467, 2054-9369
Online Access:Get full text
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Summary:The management of bacterial infections is becoming a major clinical challenge due to the rapid evolution of antibiotic resistant bacteria. As an excellent candidate to overcome antibiotic resistance, antimicrobial peptides (AMPs) that are produced from the synthetic and natural sources demonstrate a broad-spectrum antimicrobial activity with the high specificity and low toxicity. These peptides possess distinctive structures and functions by employing sophisticated mechanisms of action. This comprehensive review provides a broad overview of AMPs from the origin, structural characteristics, mechanisms of action, biological activities to clinical applications. We finally discuss the strategies to optimize and develop AMP-based treatment as the potential antimicrobial and anticancer therapeutics.
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ISSN:2054-9369
2095-7467
2054-9369
DOI:10.1186/s40779-021-00343-2