Reduced levels of NR2A and NR2B subunits of NMDA receptor and PSD-95 in the prefrontal cortex in major depression

Recent neuroimaging and postmortem studies have demonstrated abnormalities in glutamatergic transmission in major depression. Glutamate NMDA (N-methyl- d-aspartate) receptors are one of the major mediators of excitatory neurotransmission in the central nervous system. At synaptic sites, NMDA recepto...

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Bibliographic Details
Published in:	Progress in neuro-psychopharmacology & biological psychiatry Vol. 33; no. 1; pp. 70 - 75
Main Authors:	Feyissa, Anteneh M., Chandran, Agata, Stockmeier, Craig A., Karolewicz, Beata
Format:	Journal Article
Language:	English
Published:	Amsterdam Elsevier Inc 01.02.2009 Elsevier
Subjects:	Adult Adult and adolescent clinical studies Anterior prefrontal cortex Biological and medical sciences Carrier Proteins - metabolism Depression Depressive Disorder, Major - metabolism Depressive Disorder, Major - pathology Disks Large Homolog 4 Protein Female Glutamate receptors Humans Intracellular Signaling Peptides and Proteins - metabolism Major depressive disorder Male Medical sciences Membrane Proteins - metabolism Middle Aged Mood disorders Nerve Tissue Proteins - metabolism Neuropharmacology Pharmacology. Drug treatments Postmortem Postsynaptic density protein Prefrontal Cortex - metabolism Prefrontal Cortex - pathology Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Receptors, N-Methyl-D-Aspartate - metabolism Signal Transduction Glutamate receptors AMPA NR Anterior prefrontal cortex Postsynaptic density protein Postmortem NMDA MDD PFC PSD-95 Major depressive disorder Mood disorder Central nervous system Depression Glutamate receptor Prefrontal cortex Protein Encephalon Postsynaptic density NMDA receptor
ISSN:	0278-5846, 1878-4216
Online Access:	Get full text
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