Circular RNAs in cancer: opportunities and challenges in the field

Circular RNA (circRNA) is a novel member of the noncoding cancer genome with distinct properties and diverse cellular functions, which is being explored at a steadily increasing pace. The list of endogenous circRNAs involved in cancer continues to grow; however, the functional relevance of the vast...

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Vydáno v:Oncogene Ročník 37; číslo 5; s. 555 - 565
Hlavní autoři: Kristensen, L S, Hansen, T B, Venø, M T, Kjems, J
Médium: Journal Article
Jazyk:angličtina
Vydáno: London Nature Publishing Group UK 01.02.2018
Nature Publishing Group
Témata:
631/67/68
692/53/2421
Apoptosis
Cancer
Cancer treatment
Cell Biology
Circular RNA
Gene expression
Gene regulation
Genomes
Health aspects
Human Genetics
Innovations
Internal Medicine
Medical research
Medicine
Medicine & Public Health
miRNA
Oncogenes
Oncology
Precision medicine
Review
Tumorigenesis
ISSN:0950-9232, 1476-5594, 1476-5594
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Shrnutí:Circular RNA (circRNA) is a novel member of the noncoding cancer genome with distinct properties and diverse cellular functions, which is being explored at a steadily increasing pace. The list of endogenous circRNAs involved in cancer continues to grow; however, the functional relevance of the vast majority is yet to be discovered. In general, circRNAs are exceptionally stable molecules and some have been shown to function as efficient microRNA sponges with gene-regulatory potential. Many circRNAs are highly conserved and have tissue-specific expression patterns, which often do not correlate well with host gene expression. Here we review the current knowledge on circRNAs in relation to their implications in tumorigenesis as well as their potential as diagnostic and prognostic biomarkers and as possible therapeutic targets in future personalized medicine. Finally, we discuss future directions for circRNA cancer research and current caveats, which must be addressed to facilitate the translation of basic circRNA research into clinical use.
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ISSN:0950-9232
1476-5594
1476-5594
DOI:10.1038/onc.2017.361