Animal Modelling of Interstitial Cystitis/Bladder Pain Syndrome
The etiology of interstitial cystitis/bladder pain syndrome (IC/BPS) remains elusive and may involve multiple causes. To better understand its pathophysiology, many efforts have been made to create IC/BPS models. Most existing models of IC/BPS strive to recreate bladder-related features by applying...
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| Veröffentlicht in: | International neurourology journal Jg. 22; H. Suppl 1; S. S3 - 9 |
|---|---|
| Hauptverfasser: | , |
| Format: | Journal Article |
| Sprache: | Englisch |
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Korea (South)
Korean Continence Society
01.01.2018
대한배뇨장애요실금학회 |
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| ISSN: | 2093-6931, 2093-4777, 2093-6931 |
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| Abstract | The etiology of interstitial cystitis/bladder pain syndrome (IC/BPS) remains elusive and may involve multiple causes. To better understand its pathophysiology, many efforts have been made to create IC/BPS models. Most existing models of IC/BPS strive to recreate bladder-related features by applying noxious intravesical or systemic stimuli to healthy animals. These models are useful to help understand various mechanisms; however, they are limited to demonstrating how the bladder and nervous system respond to noxious stimuli, and are not representative of the complex interactions and pathophysiology of IC/BPS. To study the various factors that may be relevant for IC/BPS, at least 3 different types of animal models are commonly used: (1) bladder-centric models, (2) models with complex mechanisms, and (3) psychological and physical stressors/natural disease models. It is obvious that all aspects of the human disease cannot be mimicked by a single model. It may be the case that several models, each contributing to a piece of the puzzle, are required to recreate a reasonable picture of the pathophysiology and time course of the disease(s) diagnosed as IC/BPS, and thus to identify reasonable targets for treatment. |
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| AbstractList | The etiology of interstitial cystitis/bladder pain syndrome (IC/BPS) remains elusive and may involve multiple causes. To better understand its pathophysiology, many efforts have been made to create IC/BPS models. Most existing models of IC/BPS strive to recreate bladder-related features by applying noxious intravesical or systemic stimuli to healthy animals. These models are useful to help understand various mechanisms; however, they are limited to demonstrating how the bladder and nervous system respond to noxious stimuli, and are not representative of the complex interactions and pathophysiology of IC/BPS. To study the various factors that may be relevant for IC/BPS, at least 3 different types of animal models are commonly used: (1) bladder-centric models, (2) models with complex mechanisms, and (3) psychological and physical stressors/natural disease models. It is obvious that all aspects of the human disease cannot be mimicked by a single model. It may be the case that several models, each contributing to a piece of the puzzle, are required to recreate a reasonable picture of the pathophysiology and time course of the disease(s) diagnosed as IC/BPS, and thus to identify reasonable targets for treatment.The etiology of interstitial cystitis/bladder pain syndrome (IC/BPS) remains elusive and may involve multiple causes. To better understand its pathophysiology, many efforts have been made to create IC/BPS models. Most existing models of IC/BPS strive to recreate bladder-related features by applying noxious intravesical or systemic stimuli to healthy animals. These models are useful to help understand various mechanisms; however, they are limited to demonstrating how the bladder and nervous system respond to noxious stimuli, and are not representative of the complex interactions and pathophysiology of IC/BPS. To study the various factors that may be relevant for IC/BPS, at least 3 different types of animal models are commonly used: (1) bladder-centric models, (2) models with complex mechanisms, and (3) psychological and physical stressors/natural disease models. It is obvious that all aspects of the human disease cannot be mimicked by a single model. It may be the case that several models, each contributing to a piece of the puzzle, are required to recreate a reasonable picture of the pathophysiology and time course of the disease(s) diagnosed as IC/BPS, and thus to identify reasonable targets for treatment. The etiology of interstitial cystitis/bladder pain syndrome (IC/BPS) remains elusive and may involve multiple causes. To better understand its pathophysiology, many efforts have been made to create IC/BPS models. Most existing models of IC/BPS strive to recreate bladder-related features by applying noxious intravesical or systemic stimuli to healthy animals. These models are useful to help understand various mechanisms; however, they are limited to demonstrating how the bladder and nervous system respond to noxious stimuli, and are not representative of the complex interactions and pathophysiology of IC/BPS. To study the various factors that may be relevant for IC/BPS, at least 3 different types of animal models are commonly used: (1) bladder-centric models, (2) models with complex mechanisms, and (3) psychological and physical stressors/natural disease models. It is obvious that all aspects of the human disease cannot be mimicked by a single model. It may be the case that several models, each contributing to a piece of the puzzle, are required to recreate a reasonable picture of the pathophysiology and time course of the disease(s) diagnosed as IC/BPS, and thus to identify reasonable targets for treatment. The etiology of interstitial cystitis/bladder pain syndrome (IC/BPS) remains elusive and may involve multiple causes. To better understand its pathophysiology, many efforts have been made to create IC/BPS models. Most existing models of IC/BPS strive to recreate bladder-related features by applying noxious intravesical or systemic stimuli to healthy animals. These models are useful to help understand various mechanisms; however, they are limited to demonstrating how the bladder and nervous system respond to noxious stimuli, and are not representative of the complex interactions and pathophysiology of IC/BPS. To study the various factors that may be relevant for IC/BPS, at least 3 different types of animal models are commonly used: (1) bladder-centric models, (2) models with complex mechanisms, and (3) psychological and physical stressors/natural disease models. It is obvious that all aspects of the human disease cannot be mimicked by a single model. It may be the case that several models, each contributing toa piece of the puzzle, are required to recreate a reasonable picture of the pathophysiology and time course of the disease(s) diagnosed as IC/BPS, and thus to identify reasonable targets for treatment. The etiology of interstitial cystitis/bladder pain syndrome (IC/BPS) remains elusive and may involve multiple causes. To better understand its pathophysiology, many efforts have been made to create IC/BPS models. Most existing models of IC/BPS strive to recreate bladder-related features by applying noxious intravesical or systemic stimuli to healthy animals. These models are useful to help understand various mechanisms; however, they are limited to demonstrating how the bladder and nervous system respond to noxious stimuli, and are not representative of the complex interactions and pathophysiology of IC/BPS. To study the various factors that may be relevant for IC/BPS, at least 3 different types of animal models are commonly used: (1) bladder-centric models, (2) models with complex mechanisms, and (3) psychological and physical stressors/natural disease models. It is obvious that all aspects of the human disease cannot be mimicked by a single model. It may be the case that several models, each contributing to a piece of the puzzle, are required to recreate a reasonable picture of the pathophysiology and time course of the disease(s) diagnosed as IC/BPS, and thus to identify reasonable targets for treatment. KCI Citation Count: 33 |
| Author | Birder, Lori Andersson, Karl-Erik |
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| Copyright | Copyright © 2018 Korean Continence Society 2018 |
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| Keywords | Animal models Inflammation Mucosa Interstitial cystitis Stress Bladder pain syndrome |
| Language | English |
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| References_xml | – start-page: 422 volume-title: Pelvic organ cross-sensitization to enhance bladder and urethral pain behaviors in rats with experimental colitis year: 2015 ident: ref29 – start-page: R574 volume-title: COX-2 and prostanoid expression in micturition pathways after cyclophosphamide-induced cystitis in the rat year: 2003 ident: ref16 – start-page: 269 volume-title: Determination of mouse bladder inflammatory response to E. coli lipopolysaccharide year: 2000 ident: ref11 – start-page: 17 volume-title: A mouse model for interstitial cystitis/painful bladder syndrome based on APF inhibition of bladder epithelial repair: a pilot study year: 2012 ident: ref14 – start-page: 540 volume-title: The impact of psychosocial stress on healthy skin year: 2015 ident: ref39 – start-page: 67 volume-title: Biopsy features are associated with primary symptoms in interstitial cystitis: results from the interstitial cystitis database study year: 2001 ident: ref52 – start-page: 541 volume-title: Chronic psychological stress in high-anxiety rats induces sustained bladder hyperalgesia year: 2015 ident: ref41 – start-page: 360 volume-title: Role of c-Jun N-terminal kinase (JNK) activation in micturition reflexes in cyclophosphamide (CYP)-induced cystitis in female rats year: 2014 ident: ref25 – start-page: 967 volume-title: The effects of acute and chronic psychological stress on bladder function in a rodent model year: 2011 ident: ref42 – start-page: 60 volume-title: Diagnostic criteria, classification, and nomenclature for painful bladder syndrome/interstitial cystitis: an ESSIC proposal year: 2008 ident: ref56 – start-page: 367 volume-title: Experimental autoimmune cystitis in the Lewis rat: a potential animal model for interstitial cystitis year: 1996 ident: ref30 – volume-title: Urinary bladder distention evoked visceromotor responses as a model for bladder pain in mice year: 2014 ident: ref36 doi: 10.3791/51413 – start-page: 489 volume-title: Can the adrenergic system be implicated in the pathophysiology of bladder pain syndrome/interstitial cystitis? 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chronic pelvic pain syndromes: findings from the multidisciplinary approach to the study of chronic pelvic pain research network year: 2015 ident: ref50 – start-page: 477 volume-title: Functional, histological structure and mastocytes alterations in rat urinary bladders following acute and [corrected] chronic cyclophosphamide treatment year: 2010 ident: ref17 – start-page: R692 volume-title: Expression of corticotropin-releasing factor and CRF receptors in micturition pathways after cyclophosphamide-induced cystitis year: 2006 ident: ref22 – start-page: 75 volume-title: Inflammation characteristics in bladder pain syndrome ESSIC type 3C/classic interstitial cystitis year: 2014 ident: ref55 – start-page: 265 volume-title: Bladder pain induced by prolonged peripheral alpha 1A adrenoceptor stimulation involves the enhancement of transient receptor potential vanilloid 1 activity and an increase of urothelial adenosine triphosphate release year: 2016 ident: ref48 – start-page: 2051 volume-title: Increased plasma norepinephrine concentration in cats with interstitial cystitis year: 2001 ident: ref45 – start-page: 1272 volume-title: Time-course of alterations of bladder function following acetone-induced cystitis year: 1990 ident: ref5 – start-page: 159 volume-title: Rat urinary bladder epithelial lesions induced by acrolein year: 1989 ident: ref6 |
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| SubjectTerms | Animal models Annan medicin och hälsovetenskap Bladder pain syndrome Inflammation Interstitial cystitis Medical and Health Sciences Medicin och hälsovetenskap Mucosa Other Medical and Health Sciences Other Medical and Health Sciences not elsewhere specified Review Stress Övrig annan medicin och hälsovetenskap 비뇨기과학 |
| Title | Animal Modelling of Interstitial Cystitis/Bladder Pain Syndrome |
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