Animal Modelling of Interstitial Cystitis/Bladder Pain Syndrome

The etiology of interstitial cystitis/bladder pain syndrome (IC/BPS) remains elusive and may involve multiple causes. To better understand its pathophysiology, many efforts have been made to create IC/BPS models. Most existing models of IC/BPS strive to recreate bladder-related features by applying...

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Bibliographic Details
Published in:International neurourology journal Vol. 22; no. Suppl 1; pp. S3 - 9
Main Authors: Birder, Lori, Andersson, Karl-Erik
Format: Journal Article
Language:English
Published: Korea (South) Korean Continence Society 01.01.2018
대한배뇨장애요실금학회
Subjects:
Animal models
Annan medicin och hälsovetenskap
Bladder pain syndrome
Inflammation
Interstitial cystitis
Medical and Health Sciences
Medicin och hälsovetenskap
Mucosa
Other Medical and Health Sciences
Other Medical and Health Sciences not elsewhere specified
Review
Stress
Övrig annan medicin och hälsovetenskap
비뇨기과학
Animal models
Inflammation
Mucosa
Interstitial cystitis
Stress
Bladder pain syndrome
ISSN:2093-6931, 2093-4777, 2093-6931
Online Access:Get full text
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Summary:The etiology of interstitial cystitis/bladder pain syndrome (IC/BPS) remains elusive and may involve multiple causes. To better understand its pathophysiology, many efforts have been made to create IC/BPS models. Most existing models of IC/BPS strive to recreate bladder-related features by applying noxious intravesical or systemic stimuli to healthy animals. These models are useful to help understand various mechanisms; however, they are limited to demonstrating how the bladder and nervous system respond to noxious stimuli, and are not representative of the complex interactions and pathophysiology of IC/BPS. To study the various factors that may be relevant for IC/BPS, at least 3 different types of animal models are commonly used: (1) bladder-centric models, (2) models with complex mechanisms, and (3) psychological and physical stressors/natural disease models. It is obvious that all aspects of the human disease cannot be mimicked by a single model. It may be the case that several models, each contributing to a piece of the puzzle, are required to recreate a reasonable picture of the pathophysiology and time course of the disease(s) diagnosed as IC/BPS, and thus to identify reasonable targets for treatment.
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ISSN:2093-6931
2093-4777
2093-6931
DOI:10.5213/inj.1835062.531