Ryanodine Receptors in Islet Cell Function: Calcium Signaling, Hormone Secretion, and Diabetes

Ryanodine receptors (RyRs) are large intracellular Ca2+ release channels primarily found in muscle and nerve cells and also present at low levels in pancreatic islet endocrine cells. This review examines the role of RyRs in islet cell function, focusing on calcium signaling and hormone secretion, wh...

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Bibliographic Details
Published in:	Cells (Basel, Switzerland) Vol. 14; no. 10; p. 690
Main Author:	Islam, Md. Shahidul
Format:	Journal Article
Language:	English
Published:	Switzerland MDPI AG 10.05.2025 MDPI
Subjects:	Agonists Animals Apoptosis Beta cells beta-cell electrical activity and ryanodine receptors Caffeine Calcium (intracellular) Calcium (reticular) Calcium - metabolism Calcium channels Calcium release channels Calcium Signaling calcium signaling in beta cells Calcium signalling calcium-induced calcium release in islet cells Delta cells Dextrose Diabetes mellitus (non-insulin dependent) Diabetes Mellitus - metabolism Diabetes Mellitus, Type 2 - metabolism Endoplasmic reticulum endoplasmic reticulum stress in beta cells Enzymes Experiments Glucagon Glucagon-like peptide 1 glucagon-like peptide-1 and ryanodine receptors Glucose Hormones - metabolism Humans Insulin Insulin Secretion Insulin-Secreting Cells - metabolism Intracellular signalling Islet cells Islets of Langerhans - metabolism Isoforms Neurons Pathogenesis Phosphorylation Receptor mechanisms Review Ryanodine Receptor Calcium Release Channel - metabolism Ryanodine receptors ryanodine receptors and diabetes ryanodine receptors and insulin secretion ryanodine receptors and store-operated calcium entry ryanodine receptors in delta cells ryanodine receptors in islets cells Type 2 diabetes ryanodine receptors in delta cells ryanodine receptors and diabetes endoplasmic reticulum stress in beta cells ryanodine receptors and store-operated calcium entry beta-cell electrical activity and ryanodine receptors calcium signaling in beta cells calcium-induced calcium release in islet cells glucagon-like peptide-1 and ryanodine receptors ryanodine receptors in islets cells ryanodine receptors and insulin secretion
ISSN:	2073-4409, 2073-4409
Online Access:	Get full text
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