Global remodelling of cellular microenvironment due to loss of collagen VII

The mammalian cellular microenvironment is shaped by soluble factors and structural components, the extracellular matrix, providing physical support, regulating adhesion and signalling. A global, quantitative mass spectrometry strategy, combined with bioinformatics data processing, was developed to...

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Veröffentlicht in:	Molecular systems biology Jg. 9; H. 1; S. 657 - n/a
Hauptverfasser:	Küttner, Victoria, Mack, Claudia, Rigbolt, Kristoffer TG, Kern, Johannes S, Schilling, Oliver, Busch, Hauke, Bruckner‐Tuderman, Leena, Dengjel, Jörn
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	London Nature Publishing Group UK 16.04.2013 John Wiley & Sons, Ltd EMBO Press Nature Publishing Group Springer Nature
Schlagworte:	Basement Membrane - metabolism Basement Membrane - pathology Bioinformatics Case-Control Studies Cell adhesion & migration Cell Communication Cellular Microenvironment - genetics Cellular structure Collagen Collagen Type VII - deficiency Collagen Type VII - genetics Data processing Dermis - metabolism Dermis - pathology disease proteomics EMBO24 EMBO31 Epidermolysis Bullosa Dystrophica - genetics Epidermolysis Bullosa Dystrophica - metabolism Epidermolysis Bullosa Dystrophica - pathology Extracellular matrix extracellular matrix (ECM) Extracellular Matrix - genetics Extracellular Matrix - pathology Female Fibroblasts Fibroblasts - metabolism Fibroblasts - pathology Fragility Gene Expression Grants Growth factors Humans Infant Infant, Newborn Male Mass spectrometry Mass spectroscopy Metalloproteases - genetics Metalloproteases - metabolism MMP14 Mutation Pathogenesis Primary Cell Culture primary human fibroblasts Protein Processing, Post-Translational Proteins Proteomes Proteomics Signal transduction Skin Transforming Growth Factor beta - genetics Transforming Growth Factor beta - metabolism Germany mass spectrometry primary human fibroblasts extracellular matrix (ECM) MMP14 disease proteomics
ISSN:	1744-4292, 1744-4292
Online-Zugang:	Volltext
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