Decreased sleep stage transition pattern complexity in narcolepsy type 1

•Narcolepsy type 1 might exhibit distinctive sleep stage sequence organization and complexity.•The sleep stage transition pattern in type 1 narcolepsy is different from other hypersomnolences.•R-to-N2 transition probability <0.15 has high sensitivity and specificity for narcolepsy type 1. To anal...

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Vydáno v:Clinical neurophysiology Ročník 127; číslo 8; s. 2812 - 2819
Hlavní autoři: Ferri, Raffaele, Pizza, Fabio, Vandi, Stefano, Iloti, Martina, Plazzi, Giuseppe
Médium: Journal Article
Jazyk:angličtina
Vydáno: Netherlands Elsevier B.V 01.08.2016
Témata:
Adolescent
Adult
Brain - physiopathology
Disorders of Excessive Somnolence - physiopathology
Entropy rate
Female
Humans
Hypersomnolence, Idiopathic - physiopathology
Idiopathic hypersomnia
Male
Markov process
Middle Aged
Narcolepsy - physiopathology
Narcolepsy type 1
Narcolepsy type 2
Neurology
Polysomnography
Sleep stage transitions
Sleep Stages - physiology
Subjective hypersomnolence
Young Adult
Markov process
Idiopathic hypersomnia
CDH
H0
H1
NT1
MSLT
Sleep stage transitions
NT2
TPM
SOREMP
Narcolepsy type 1
Subjective hypersomnolence
Entropy rate
Narcolepsy type 2
IH
sHS
narcolepsy type 1
sleep onset REM period
zero-memory Markov model entropy rate
narcolepsy type 2
multiple sleep latency test
subjective hypersomnolence
central disorder of hypersomnolence
transition probability matrix
idiopathic hypersomnia
first-order Markov model entropy rate
ISSN:1388-2457, 1872-8952, 1872-8952
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Shrnutí:•Narcolepsy type 1 might exhibit distinctive sleep stage sequence organization and complexity.•The sleep stage transition pattern in type 1 narcolepsy is different from other hypersomnolences.•R-to-N2 transition probability <0.15 has high sensitivity and specificity for narcolepsy type 1. To analyze the complexity of the nocturnal sleep stage sequence in central disorders of hypersomnolence (CDH), with the hypothesis that narcolepsy type 1 (NT1) might exhibit distinctive sleep stage sequence organization and complexity. Seventy-nine NT1 patients, 22 narcolepsy type 2 (NT2), 22 idiopathic hypersomnia (IH), and 52 patients with subjective hypersomnolence (sHS) were recruited and their nocturnal sleep was polysomnographically recorded and scored. Group between-stage transition probability matrices were obtained and compared. Patients with NT1 differed significantly from all the other patient groups, the latter, in turn, were not different between each other. The individual probability of the R-to-N2 transition was found to be the parameter showing the difference of highest significance between the groups (lowest in NT1) and classified patients with or without NT1 with an accuracy of 78.9% (sensitivity 78.5% and specificity 79.2%), by applying a cut-off value of 0.15. The main result of this study is that the structure of the sleep stage transition pattern of hypocretin-deficient NT1 patients is significantly different from that of other forms of CDH and sHS, with normal hypocretin levels. The lower probability of R-to-N2 transition occurrence in NT1 appears to be a reliable polysomnographic feature with potential application at the individual level, for supportive diagnostic purposes.
Bibliografie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1388-2457
1872-8952
1872-8952
DOI:10.1016/j.clinph.2016.05.364