Association between Type 2 Diabetes Mellitus and Brain Atrophy: A Meta-Analysis

Background: Type 2 diabetes mellitus (T2DM) is known to be associated with cognitive decline and brain structural changes. This study systematically reviews and estimates human brain volumetric differences and atrophy associated with T2DM.Methods: PubMed, PsycInfo and Cochrane Library were searched...

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Vydané v:Diabetes & metabolism journal Ročník 46; číslo 5; s. 781 - 802
Hlavní autori: Zhang, Tianqi, Shaw, Marnie, Cherbuin, Nicolas
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: Korea (South) Korean Diabetes Association / Daehan Dangnyobyeong Hakoe 01.09.2022
Korean Diabetes Association
대한당뇨병학회
Predmet:
Atrophy
brain
Dementia
Diabetes
diabetes mellitus
Glucose
Hyperglycemia
Insulin resistance
Longitudinal studies
Magnetic resonance imaging
Meta-analysis
neuroimaging
Original
Sample size
Statistical analysis
Systematic review
Tomography
type 2
내과학
Atrophy
Neuroimaging
Brain
Diabetes mellitus, type 2
ISSN:2233-6079, 2233-6087, 2233-6087
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Shrnutí:Background: Type 2 diabetes mellitus (T2DM) is known to be associated with cognitive decline and brain structural changes. This study systematically reviews and estimates human brain volumetric differences and atrophy associated with T2DM.Methods: PubMed, PsycInfo and Cochrane Library were searched for brain imaging studies reporting on brain volume differences between individuals with T2DM and healthy controls. Data were examined using meta-analysis, and association between age, sex, diabetes characteristics and brain volumes were tested using meta-regression.Results: A total of 14,605 entries were identified; after title, abstract and full-text screening applying inclusion and exclusion criteria, 64 studies were included and 42 studies with compatible data contributed to the meta-analysis (n=31,630; mean age 71.0 years; 44.4% male; 26,942 control; 4,688 diabetes). Individuals with T2DM had significantly smaller total brain volume, total grey matter volume, total white matter volume and hippocampal volume (approximately 1% to 4%); meta-analyses of smaller samples focusing on other brain regions and brain atrophy rate in longitudinal investigations also indicated smaller brain volumes and greater brain atrophy associated with T2DM. Meta-regression suggests that diabetes-related brain volume differences start occurring in early adulthood, decreases with age and increases with diabetes duration.Conclusion: T2DM is associated with smaller total and regional brain volume and greater atrophy over time. These effects are substantial and highlight an urgent need to develop interventions to reduce the risk of T2DM for brain health.
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https://e-dmj.org/journal/view.php?number=2641
ISSN:2233-6079
2233-6087
2233-6087
DOI:10.4093/dmj.2021.0189