Noncoding RNAs Controlling Telomere Homeostasis in Senescence and Aging

Aging is a universal and time-dependent biological decline associated with progressive deterioration of cells, tissues, and organs. Age-related decay can eventually lead to pathology such as cardiovascular and neurodegenerative diseases, cancer, and diabetes. A prominent molecular process underlying...

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Bibliographic Details
Published in:Trends in molecular medicine Vol. 26; no. 4; pp. 422 - 433
Main Authors: Rossi, Martina, Gorospe, Myriam
Format: Journal Article
Language:English
Published: England Elsevier Ltd 01.04.2020
Subjects:
Aging - genetics
Animals
Cellular Senescence - genetics
genomic instability
Homeostasis - genetics
Humans
long noncoding RNAs
miRNA
RNA, Untranslated - genetics
telomerase activity
Telomere - genetics
Telomere Homeostasis - genetics
TERC
TERT
miRNA
telomerase activity
long noncoding RNAs
TERT
genomic instability
TERC
ISSN:1471-4914, 1471-499X, 1471-499X
Online Access:Get full text
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Summary:Aging is a universal and time-dependent biological decline associated with progressive deterioration of cells, tissues, and organs. Age-related decay can eventually lead to pathology such as cardiovascular and neurodegenerative diseases, cancer, and diabetes. A prominent molecular process underlying aging is the progressive shortening of telomeres, the structures that protect the ends of chromosomes, eventually triggering cellular senescence. Noncoding (nc)RNAs are emerging as major regulators of telomere length homeostasis. In this review, we describe the impact of ncRNAs on telomere function and discuss their implications in senescence and age-related diseases. We discuss emerging therapeutic strategies targeting telomere-regulatory ncRNAs in aging pathology. Senescent cells accumulating in aging tissues display indefinite cell cycle arrest, shortened telomeres, and enhanced secretion of proinflammatory factors.ncRNAs critically regulate gene expression programs in many physiological and pathological processes, including those associated with aging.ncRNAs regulate telomere homeostasis, either directly or indirectly, and thereby coordinate molecular processes inherent to cellular senescence and aging.
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ISSN:1471-4914
1471-499X
1471-499X
DOI:10.1016/j.molmed.2020.01.010