Intratracheal cell transfer demonstrates the profibrotic potential of resident fibroblasts in pulmonary fibrosis

Pulmonary fibrosis is a devastating disease for which there are few effective therapies. Activated fibroblasts form subepithelial clusters known as fibroblastic foci, which are characterized by excessive collagen deposition. The origin of activated fibroblasts is controversial and needs to be clarif...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The American journal of pathology Jg. 185; H. 11; S. 2939
Hauptverfasser:	Tsukui, Tatsuya, Ueha, Satoshi, Shichino, Shigeyuki, Inagaki, Yutaka, Matsushima, Kouji
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 01.11.2015
Schlagworte:	Animals Bleomycin - adverse effects Collagen - metabolism Disease Models, Animal Epithelial Cells - metabolism Epithelial Cells - pathology Epithelium - metabolism Epithelium - pathology Female Fibroblasts - metabolism Fibroblasts - pathology Gene Expression Regulation Genes, Reporter Male Mice Mice, Inbred C57BL Mice, Transgenic Pulmonary Alveoli - metabolism Pulmonary Alveoli - pathology Pulmonary Fibrosis - metabolism Pulmonary Fibrosis - pathology Up-Regulation
ISSN:	1525-2191, 1525-2191
Online-Zugang:	Weitere Angaben
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!