The CIRCORT database: Reference ranges and seasonal changes in diurnal salivary cortisol derived from a meta-dataset comprised of 15 field studies

•The CIRCORT database comprises 104,623 saliva cortisol samples from 18,698 individuals.•Lifespan- and sex-specific reference ranges (LC/MS-MS) for diurnal salivary cortisol were derived.•A seasonal rhythm underlying diurnal salivary cortisol (acrophase: spring) was confirmed. Diurnal salivary corti...

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Vydáno v:Psychoneuroendocrinology Ročník 73; s. 16 - 23
Hlavní autoři: Miller, Robert, Stalder, Tobias, Jarczok, Marc, Almeida, David M., Badrick, Ellena, Bartels, Meike, Boomsma, Dorret I., Coe, Christopher L., Dekker, Marieke C.J., Donzella, Bonny, Fischer, Joachim E., Gunnar, Megan R., Kumari, Meena, Lederbogen, Florian, Power, Christine, Ryff, Carol D., Subramanian, S.V., Tiemeier, Henning, Watamura, Sarah E., Kirschbaum, Clemens
Médium: Journal Article
Jazyk:angličtina
Vydáno: England Elsevier Ltd 01.11.2016
Témata:
Adolescent
Adult
Aged
Aged, 80 and over
Child
Child, Preschool
Circadian rhythm
Circadian Rhythm - physiology
Cortisol
Datasets as Topic - statistics & numerical data
Endocrinology & Metabolism
Europe
Female
Humans
Hydrocortisone - metabolism
Infant
Lifespan
Male
Middle Aged
Psychiatry
Reference value
Reference Values
Saliva
Saliva - chemistry
Seasons
United States
Young Adult
Reference value
Cortisol
Circadian rhythm
Saliva
Lifespan
saliva
cortisol
lifespan
reference value
circadian rhythm
ISSN:0306-4530, 1873-3360, 1873-3360
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Popis
Shrnutí:•The CIRCORT database comprises 104,623 saliva cortisol samples from 18,698 individuals.•Lifespan- and sex-specific reference ranges (LC/MS-MS) for diurnal salivary cortisol were derived.•A seasonal rhythm underlying diurnal salivary cortisol (acrophase: spring) was confirmed. Diurnal salivary cortisol profiles are valuable indicators of adrenocortical functioning in epidemiological research and clinical practice. However, normative reference values derived from a large number of participants and across a wide age range are still missing. To fill this gap, data were compiled from 15 independently conducted field studies with a total of 104,623 salivary cortisol samples obtained from 18,698 unselected individuals (mean age: 48.3 years, age range: 0.5–98.5 years, 39% females). Besides providing a descriptive analysis of the complete dataset, we also performed mixed-effects growth curve modeling of diurnal salivary cortisol (i.e., 1–16h after awakening). Cortisol decreased significantly across the day and was influenced by both, age and sex. Intriguingly, we also found a pronounced impact of sampling season with elevated diurnal cortisol in spring and decreased levels in autumn. However, the majority of variance was accounted for by between-participant and between-study variance components. Based on these analyses, reference ranges (LC/MS–MS calibrated) for cortisol concentrations in saliva were derived for different times across the day, with more specific reference ranges generated for males and females in different age categories. This integrative summary provides important reference values on salivary cortisol to aid basic scientists and clinicians in interpreting deviations from the normal diurnal cycle.
Bibliografie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0306-4530
1873-3360
1873-3360
DOI:10.1016/j.psyneuen.2016.07.201