Progressive Loss of Function in a Limb Enhancer during Snake Evolution

The evolution of body shape is thought to be tightly coupled to changes in regulatory sequences, but specific molecular events associated with major morphological transitions in vertebrates have remained elusive. We identified snake-specific sequence changes within an otherwise highly conserved long...

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Veröffentlicht in:	Cell Jg. 167; H. 3; S. 633
Hauptverfasser:	Kvon, Evgeny Z, Kamneva, Olga K, Melo, Uirá S, Barozzi, Iros, Osterwalder, Marco, Mannion, Brandon J, Tissières, Virginie, Pickle, Catherine S, Plajzer-Frick, Ingrid, Lee, Elizabeth A, Kato, Momoe, Garvin, Tyler H, Akiyama, Jennifer A, Afzal, Veena, Lopez-Rios, Javier, Rubin, Edward M, Dickel, Diane E, Pennacchio, Len A, Visel, Axel
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 20.10.2016
Schlagworte:	Animals Base Sequence Biological Evolution Enhancer Elements, Genetic Evolution, Molecular Extremities - growth & development Gene Knock-In Techniques Hedgehog Proteins - genetics Mice Mice, Transgenic Mutation Phylogeny Snakes - classification Snakes - genetics evo-devo limb development genome editing Sonic hedgehog (Shh) enhancer CRISPR/Cas9 cis-regulatory element morphological evolution ZRS snakes
ISSN:	1097-4172, 1097-4172
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