Global remodeling of the mouse DNA methylome during aging and in response to calorie restriction

Summary Aging is characterized by numerous molecular changes, such as accumulation of molecular damage and altered gene expression, many of which are linked to DNA methylation. Here, we characterize the blood DNA methylome across 16 age groups of mice and report numerous global, region‐ and site‐spe...

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Bibliographic Details
Published in:	Aging cell Vol. 17; no. 3; pp. e12738 - n/a
Main Authors:	Sziráki, András, Tyshkovskiy, Alexander, Gladyshev, Vadim N.
Format:	Journal Article
Language:	English
Published:	England John Wiley & Sons, Inc 01.06.2018 John Wiley and Sons Inc
Subjects:	Age Aging Aging - genetics Animals Caloric Restriction - methods calorie restriction Deoxyribonucleic acid DNA DNA - genetics DNA methylation DNA Methylation - genetics Entropy Gene expression Genes Life span Methylation Mice Nutrient deficiency Original DNA methylation calorie restriction entropy aging
ISSN:	1474-9718, 1474-9726, 1474-9726
Online Access:	Get full text
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