Folding–unfolding asymmetry and a RetroFold computational algorithm

We treat protein folding as molecular self-assembly, while unfolding is viewed as disassembly. Fracture is typically a much faster process than self-assembly. Self-assembly is often an exponentially decaying process, since energy relaxes due to dissipation, while fracture is a constant-rate process...

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Veröffentlicht in:	Royal Society open science Jg. 10; H. 5; S. 221594
Hauptverfasser:	Shityakov, Sergey, Skorb, Ekaterina V., Nosonovsky, Michael
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	England The Royal Society 03.05.2023
Schlagworte:	Biochemistry, Cellular and Molecular Biology folding molecular dynamics RetroFold algorithm Trp-cage unfolding RetroFold algorithm molecular dynamics unfolding Trp-cage folding
ISSN:	2054-5703, 2054-5703
Online-Zugang:	Volltext
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