Capmatinib is an effective treatment for MET-fusion driven pediatric high-grade glioma and synergizes with radiotherapy

Background Pediatric-type diffuse high-grade glioma (pHGG) is the most frequent malignant brain tumor in children and can be subclassified into multiple entities. Fusion genes activating the MET receptor tyrosine kinase often occur in infant-type hemispheric glioma (IHG) but also in other pHGG and a...

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Bibliographic Details
Published in:	Molecular cancer Vol. 23; no. 1; pp. 123 - 19
Main Authors:	Zuckermann, Marc, He, Chen, Andrews, Jared, Bagchi, Aditi, Sloan-Henry, Roketa, Bianski, Brandon, Xie, Jia, Wang, Yingzhe, Twarog, Nathaniel, Onar-Thomas, Arzu, Ernst, Kati J., Yang, Lei, Li, Yong, Zhu, Xiaoyan, Ocasio, Jennifer K., Budd, Kaitlin M., Dalton, James, Li, Xiaoyu, Chepyala, Divyabharathi, Zhang, Junyuan, Xu, Ke, Hover, Laura, Roach, Jordan T., Chan, Kenneth Chun-Ho, Hofmann, Nina, McKinnon, Peter J., Pfister, Stefan M., Shelat, Anang A., Rankovic, Zoran, Freeman, Burgess B., Chiang, Jason, Jones, David T. W., Tinkle, Christopher L., Baker, Suzanne J.
Format:	Journal Article
Language:	English
Published:	London BioMed Central 07.06.2024 BioMed Central Ltd BMC
Subjects:	Anilides - pharmacology Animals Benzamides - pharmacology Benzamides - therapeutic use Biomedical and Life Sciences Biomedicine Brain Neoplasms - drug therapy Brain Neoplasms - genetics Brain Neoplasms - pathology Brain Neoplasms - radiotherapy Brain tumors Cancer Research Capmatinib Cell Line, Tumor Child Combination therapy Crizotinib - pharmacology Crizotinib - therapeutic use Disease Models, Animal Female Glioma - drug therapy Glioma - genetics Glioma - pathology Glioma - therapy Gliomas Humans Imidazoles MET inhibition Mice Neoplasm Grading Oncogene Proteins, Fusion - genetics Oncogene Proteins, Fusion - metabolism Oncology Pediatric-type diffuse high-grade glioma Pediatrics Preclinical trials Protein Kinase Inhibitors - pharmacology Protein Kinase Inhibitors - therapeutic use Proto-Oncogene Proteins c-met - antagonists & inhibitors Proto-Oncogene Proteins c-met - genetics Proto-Oncogene Proteins c-met - metabolism Pyridines - pharmacology Pyridines - therapeutic use Radiation Radiosensitization Radiotherapy Triazines Tyrosine Xenograft Model Antitumor Assays Pediatric-type diffuse high-grade glioma MET inhibition Radiosensitization Combination therapy Capmatinib Preclinical trials
ISSN:	1476-4598, 1476-4598
Online Access:	Get full text
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