Age related human T cell subset evolution and senescence

T cells are fundamental effector cells against viruses and cancers that can be divided into different subsets based on their long-term immune protection and immediate immune response effects. The percentage and absolute number of these subsets change with ageing, which leads to a reduced immune resp...

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Veröffentlicht in:	Immunity & ageing Jg. 16; H. 1; S. 24 - 7
Hauptverfasser:	Li, Mingde, Yao, Danlin, Zeng, Xiangbo, Kasakovski, Dimitri, Zhang, Yikai, Chen, Shaohua, Zha, Xianfeng, Li, Yangqiu, Xu, Ling
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	London BioMed Central 11.09.2019 BioMed Central Ltd Springer Nature B.V BMC
Schlagworte:	Age Ageing Aging Antibodies B cells Biomedical and Life Sciences Biomedicine Cancer prevention CD4 antigen CD8 antigen Cell differentiation Cell proliferation Central memory T cells Clinical Nutrition Effector cells Effector memory T cells Flow cytometry Geriatrics/Gerontology Homeostasis Immune response Immunological memory Immunology Immunosenescence Lymphocytes Lymphocytes T Medical schools Memory cells Peripheral blood Public Health Senescence Short Report Stem cell memory T cell Stem cells T cells Effector memory T cells Immunosenescence Stem cell memory T cell Central memory T cells Ageing
ISSN:	1742-4933, 1742-4933
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Abstract	T cells are fundamental effector cells against viruses and cancers that can be divided into different subsets based on their long-term immune protection and immediate immune response effects. The percentage and absolute number of these subsets change with ageing, which leads to a reduced immune response in older individuals. Stem cell memory T cells (T SCM ) represent a small population of memory T cells with enhanced proliferation and differentiation properties that are endowed with high potential for maintaining T cell homeostasis. However, whether these cells change with ageing and gender remains unknown. Here, we assayed the distribution of T SCM and other T cell subsets in peripheral blood from 92 healthy subjects (44 females and 48 males) ranging from 3 to 88 years old by flow cytometry. We found that CD4+ and CD8+ T SCM in the circulation have relatively stable frequencies, and the absolute number of CD8+ T SCM decreased with age; however, the ratio of T SCM to the CD4+ or CD8+ naïve population increased with age. Unlike the obvious changes in other T cell subsets with age and gender, the stable level of T SCM in peripheral blood may support their capacity for sustaining long-term immunological memory, while their importance may increase together with ageing.
AbstractList	T cells are fundamental effector cells against viruses and cancers that can be divided into different subsets based on their long-term immune protection and immediate immune response effects. The percentage and absolute number of these subsets change with ageing, which leads to a reduced immune response in older individuals. Stem cell memory T cells (TSCM) represent a small population of memory T cells with enhanced proliferation and differentiation properties that are endowed with high potential for maintaining T cell homeostasis. However, whether these cells change with ageing and gender remains unknown. Here, we assayed the distribution of TSCM and other T cell subsets in peripheral blood from 92 healthy subjects (44 females and 48 males) ranging from 3 to 88 years old by flow cytometry. We found that CD4+ and CD8+ TSCM in the circulation have relatively stable frequencies, and the absolute number of CD8+ TSCM decreased with age; however, the ratio of TSCM to the CD4+ or CD8+ naïve population increased with age. Unlike the obvious changes in other T cell subsets with age and gender, the stable level of TSCM in peripheral blood may support their capacity for sustaining long-term immunological memory, while their importance may increase together with ageing.T cells are fundamental effector cells against viruses and cancers that can be divided into different subsets based on their long-term immune protection and immediate immune response effects. The percentage and absolute number of these subsets change with ageing, which leads to a reduced immune response in older individuals. Stem cell memory T cells (TSCM) represent a small population of memory T cells with enhanced proliferation and differentiation properties that are endowed with high potential for maintaining T cell homeostasis. However, whether these cells change with ageing and gender remains unknown. Here, we assayed the distribution of TSCM and other T cell subsets in peripheral blood from 92 healthy subjects (44 females and 48 males) ranging from 3 to 88 years old by flow cytometry. We found that CD4+ and CD8+ TSCM in the circulation have relatively stable frequencies, and the absolute number of CD8+ TSCM decreased with age; however, the ratio of TSCM to the CD4+ or CD8+ naïve population increased with age. Unlike the obvious changes in other T cell subsets with age and gender, the stable level of TSCM in peripheral blood may support their capacity for sustaining long-term immunological memory, while their importance may increase together with ageing. Abstract T cells are fundamental effector cells against viruses and cancers that can be divided into different subsets based on their long-term immune protection and immediate immune response effects. The percentage and absolute number of these subsets change with ageing, which leads to a reduced immune response in older individuals. Stem cell memory T cells (TSCM) represent a small population of memory T cells with enhanced proliferation and differentiation properties that are endowed with high potential for maintaining T cell homeostasis. However, whether these cells change with ageing and gender remains unknown. Here, we assayed the distribution of TSCM and other T cell subsets in peripheral blood from 92 healthy subjects (44 females and 48 males) ranging from 3 to 88 years old by flow cytometry. We found that CD4+ and CD8+ TSCM in the circulation have relatively stable frequencies, and the absolute number of CD8+ TSCM decreased with age; however, the ratio of TSCM to the CD4+ or CD8+ naïve population increased with age. Unlike the obvious changes in other T cell subsets with age and gender, the stable level of TSCM in peripheral blood may support their capacity for sustaining long-term immunological memory, while their importance may increase together with ageing. T cells are fundamental effector cells against viruses and cancers that can be divided into different subsets based on their long-term immune protection and immediate immune response effects. The percentage and absolute number of these subsets change with ageing, which leads to a reduced immune response in older individuals. Stem cell memory T cells (T SCM ) represent a small population of memory T cells with enhanced proliferation and differentiation properties that are endowed with high potential for maintaining T cell homeostasis. However, whether these cells change with ageing and gender remains unknown. Here, we assayed the distribution of T SCM and other T cell subsets in peripheral blood from 92 healthy subjects (44 females and 48 males) ranging from 3 to 88 years old by flow cytometry. We found that CD4+ and CD8+ T SCM in the circulation have relatively stable frequencies, and the absolute number of CD8+ T SCM decreased with age; however, the ratio of T SCM to the CD4+ or CD8+ naïve population increased with age. Unlike the obvious changes in other T cell subsets with age and gender, the stable level of T SCM in peripheral blood may support their capacity for sustaining long-term immunological memory, while their importance may increase together with ageing. T cells are fundamental effector cells against viruses and cancers that can be divided into different subsets based on their long-term immune protection and immediate immune response effects. The percentage and absolute number of these subsets change with ageing, which leads to a reduced immune response in older individuals. Stem cell memory T cells (TSCM) represent a small population of memory T cells with enhanced proliferation and differentiation properties that are endowed with high potential for maintaining T cell homeostasis. However, whether these cells change with ageing and gender remains unknown. Here, we assayed the distribution of TSCM and other T cell subsets in peripheral blood from 92 healthy subjects (44 females and 48 males) ranging from 3 to 88 years old by flow cytometry. We found that CD4+ and CD8+ TSCM in the circulation have relatively stable frequencies, and the absolute number of CD8+ TSCM decreased with age; however, the ratio of TSCM to the CD4+ or CD8+ naïve population increased with age. Unlike the obvious changes in other T cell subsets with age and gender, the stable level of TSCM in peripheral blood may support their capacity for sustaining long-term immunological memory, while their importance may increase together with ageing. T cells are fundamental effector cells against viruses and cancers that can be divided into different subsets based on their long-term immune protection and immediate immune response effects. The percentage and absolute number of these subsets change with ageing, which leads to a reduced immune response in older individuals. Stem cell memory T cells (T.sub.SCM) represent a small population of memory T cells with enhanced proliferation and differentiation properties that are endowed with high potential for maintaining T cell homeostasis. However, whether these cells change with ageing and gender remains unknown. Here, we assayed the distribution of T.sub.SCM and other T cell subsets in peripheral blood from 92 healthy subjects (44 females and 48 males) ranging from 3 to 88 years old by flow cytometry. We found that CD4+ and CD8+ T.sub.SCM in the circulation have relatively stable frequencies, and the absolute number of CD8+ T.sub.SCM decreased with age; however, the ratio of T.sub.SCM to the CD4+ or CD8+ naïve population increased with age. Unlike the obvious changes in other T cell subsets with age and gender, the stable level of T.sub.SCM in peripheral blood may support their capacity for sustaining long-term immunological memory, while their importance may increase together with ageing. Keywords: Stem cell memory T cell, Central memory T cells, Effector memory T cells, Ageing, Immunosenescence T cells are fundamental effector cells against viruses and cancers that can be divided into different subsets based on their long-term immune protection and immediate immune response effects. The percentage and absolute number of these subsets change with ageing, which leads to a reduced immune response in older individuals. Stem cell memory T cells (T.sub.SCM) represent a small population of memory T cells with enhanced proliferation and differentiation properties that are endowed with high potential for maintaining T cell homeostasis. However, whether these cells change with ageing and gender remains unknown. Here, we assayed the distribution of T.sub.SCM and other T cell subsets in peripheral blood from 92 healthy subjects (44 females and 48 males) ranging from 3 to 88 years old by flow cytometry. We found that CD4+ and CD8+ T.sub.SCM in the circulation have relatively stable frequencies, and the absolute number of CD8+ T.sub.SCM decreased with age; however, the ratio of T.sub.SCM to the CD4+ or CD8+ naïve population increased with age. Unlike the obvious changes in other T cell subsets with age and gender, the stable level of T.sub.SCM in peripheral blood may support their capacity for sustaining long-term immunological memory, while their importance may increase together with ageing.
ArticleNumber	24
Audience	Academic
Author	Chen, Shaohua Zeng, Xiangbo Zhang, Yikai Zha, Xianfeng Li, Yangqiu Yao, Danlin Xu, Ling Li, Mingde Kasakovski, Dimitri
Author_xml	– sequence: 1 givenname: Mingde surname: Li fullname: Li, Mingde organization: Department of Hematology, First Affiliated Hospital; Institute of Hematology, School of Medicine; Key Laboratory for Regenerative Medicine of Ministry of Education, Jinan University – sequence: 2 givenname: Danlin surname: Yao fullname: Yao, Danlin organization: Department of Hematology, First Affiliated Hospital; Institute of Hematology, School of Medicine; Key Laboratory for Regenerative Medicine of Ministry of Education, Jinan University – sequence: 3 givenname: Xiangbo surname: Zeng fullname: Zeng, Xiangbo organization: Department of Hematology, First Affiliated Hospital; Institute of Hematology, School of Medicine; Key Laboratory for Regenerative Medicine of Ministry of Education, Jinan University – sequence: 4 givenname: Dimitri surname: Kasakovski fullname: Kasakovski, Dimitri organization: Department of Hematology, First Affiliated Hospital; Institute of Hematology, School of Medicine; Key Laboratory for Regenerative Medicine of Ministry of Education, Jinan University – sequence: 5 givenname: Yikai surname: Zhang fullname: Zhang, Yikai organization: Department of Hematology, First Affiliated Hospital; Institute of Hematology, School of Medicine; Key Laboratory for Regenerative Medicine of Ministry of Education, Jinan University – sequence: 6 givenname: Shaohua surname: Chen fullname: Chen, Shaohua organization: Department of Hematology, First Affiliated Hospital; Institute of Hematology, School of Medicine; Key Laboratory for Regenerative Medicine of Ministry of Education, Jinan University – sequence: 7 givenname: Xianfeng surname: Zha fullname: Zha, Xianfeng organization: Department of Clinical Laboratory, First Affiliated Hospital, Jinan University – sequence: 8 givenname: Yangqiu surname: Li fullname: Li, Yangqiu email: yangqiuli@hotmail.com organization: Department of Hematology, First Affiliated Hospital; Institute of Hematology, School of Medicine; Key Laboratory for Regenerative Medicine of Ministry of Education, Jinan University – sequence: 9 givenname: Ling surname: Xu fullname: Xu, Ling email: lingxu114@163.com organization: Department of Hematology, First Affiliated Hospital; Institute of Hematology, School of Medicine; Key Laboratory for Regenerative Medicine of Ministry of Education, Jinan University, The Clinical Medicine Postdoctoral Research Station, Jinan University
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Keywords	Effector memory T cells Immunosenescence Stem cell memory T cell Central memory T cells Ageing
Language	English
License	Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
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PublicationTitle	Immunity & ageing
PublicationTitleAbbrev	Immun Ageing
PublicationYear	2019
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Snippet	T cells are fundamental effector cells against viruses and cancers that can be divided into different subsets based on their long-term immune protection and... Abstract T cells are fundamental effector cells against viruses and cancers that can be divided into different subsets based on their long-term immune...
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SubjectTerms	Age Ageing Aging Antibodies B cells Biomedical and Life Sciences Biomedicine Cancer prevention CD4 antigen CD8 antigen Cell differentiation Cell proliferation Central memory T cells Clinical Nutrition Effector cells Effector memory T cells Flow cytometry Geriatrics/Gerontology Homeostasis Immune response Immunological memory Immunology Immunosenescence Lymphocytes Lymphocytes T Medical schools Memory cells Peripheral blood Public Health Senescence Short Report Stem cell memory T cell Stem cells T cells
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Title	Age related human T cell subset evolution and senescence
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