Age related human T cell subset evolution and senescence

T cells are fundamental effector cells against viruses and cancers that can be divided into different subsets based on their long-term immune protection and immediate immune response effects. The percentage and absolute number of these subsets change with ageing, which leads to a reduced immune resp...

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Vydáno v:Immunity & ageing Ročník 16; číslo 1; s. 24 - 7
Hlavní autoři: Li, Mingde, Yao, Danlin, Zeng, Xiangbo, Kasakovski, Dimitri, Zhang, Yikai, Chen, Shaohua, Zha, Xianfeng, Li, Yangqiu, Xu, Ling
Médium: Journal Article
Jazyk:angličtina
Vydáno: London BioMed Central 11.09.2019
BioMed Central Ltd
Springer Nature B.V
BMC
Témata:
Age
Ageing
Aging
Antibodies
B cells
Biomedical and Life Sciences
Biomedicine
Cancer prevention
CD4 antigen
CD8 antigen
Cell differentiation
Cell proliferation
Central memory T cells
Clinical Nutrition
Effector cells
Effector memory T cells
Flow cytometry
Geriatrics/Gerontology
Homeostasis
Immune response
Immunological memory
Immunology
Immunosenescence
Lymphocytes
Lymphocytes T
Medical schools
Memory cells
Peripheral blood
Public Health
Senescence
Short Report
Stem cell memory T cell
Stem cells
T cells
Effector memory T cells
Immunosenescence
Stem cell memory T cell
Central memory T cells
Ageing
ISSN:1742-4933, 1742-4933
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Shrnutí:T cells are fundamental effector cells against viruses and cancers that can be divided into different subsets based on their long-term immune protection and immediate immune response effects. The percentage and absolute number of these subsets change with ageing, which leads to a reduced immune response in older individuals. Stem cell memory T cells (T SCM ) represent a small population of memory T cells with enhanced proliferation and differentiation properties that are endowed with high potential for maintaining T cell homeostasis. However, whether these cells change with ageing and gender remains unknown. Here, we assayed the distribution of T SCM and other T cell subsets in peripheral blood from 92 healthy subjects (44 females and 48 males) ranging from 3 to 88 years old by flow cytometry. We found that CD4+ and CD8+ T SCM in the circulation have relatively stable frequencies, and the absolute number of CD8+ T SCM decreased with age; however, the ratio of T SCM to the CD4+ or CD8+ naïve population increased with age. Unlike the obvious changes in other T cell subsets with age and gender, the stable level of T SCM in peripheral blood may support their capacity for sustaining long-term immunological memory, while their importance may increase together with ageing.
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ISSN:1742-4933
1742-4933
DOI:10.1186/s12979-019-0165-8