Pro-B cells sense productive immunoglobulin heavy chain rearrangement irrespective of polypeptide production

B-lymphocyte development is dictated by the protein products of functionally rearranged Ig heavy (H) and light (L) chain genes. Ig rearrangement begins in pro-B cells at the IgH locus. If pro-B cells generate a productive allele, they assemble a pre-B cell receptor complex, which signals their diffe...

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Vydané v:	Proceedings of the National Academy of Sciences - PNAS Ročník 108; číslo 26; s. 10644
Hlavní autori:	Lutz, Johannes, Heideman, Marinus R, Roth, Edith, van den Berk, Paul, Müller, Werner, Raman, Chander, Wabl, Matthias, Jacobs, Heinz, Jäck, Hans-Martin
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States 28.06.2011
Predmet:	Alleles Animals B-Lymphocytes - immunology Immunoglobulin Heavy Chains - genetics Mice Peptide Biosynthesis RNA, Messenger - genetics RNA, Untranslated - genetics VDJ Recombinases - metabolism
ISSN:	1091-6490, 1091-6490
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