Vitamin D, a modulator of musculoskeletal health in chronic kidney disease

The spectrum of activity of vitamin D goes beyond calcium and bone homeostasis, and growing evidence suggests that vitamin D contributes to maintain musculoskeletal health in healthy subjects as well as in patients with chronic kidney disease (CKD), who display the combination of bone metabolism dis...

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Veröffentlicht in:	Journal of cachexia, sarcopenia and muscle Jg. 8; H. 5; S. 686 - 701
Hauptverfasser:	Molina, Pablo, Carrero, Juan J., Bover, Jordi, Chauveau, Philippe, Mazzaferro, Sandro, Torres, Pablo Ureña
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	Germany John Wiley & Sons, Inc 01.10.2017 John Wiley and Sons Inc
Schlagworte:	Animals Bone Bone and Bones - metabolism Bone Density Bone Diseases, Metabolic - etiology Bone Diseases, Metabolic - metabolism Chronic kidney disease Fibroblasts Fractures Gene expression Growth factors Homeostasis Humans Kidney diseases Kinases Metabolism Mineralization Muscle Muscle function Muscle Weakness - etiology Muscle Weakness - metabolism Muscles - metabolism Muscular Diseases - etiology Muscular Diseases - metabolism Musculoskeletal System - metabolism Nutrition Phosphatase Physical performance Proteins Receptors, Calcitriol - metabolism Renal Insufficiency, Chronic - complications Renal Insufficiency, Chronic - etiology Renal Insufficiency, Chronic - metabolism Review Reviews Sarcopenia Signal Transduction Vitamin D Vitamin D - metabolism Vitamin D Deficiency - etiology Vitamin D Deficiency - metabolism Vitamin deficiency Working groups Italy Netherlands United Kingdom > UK France Germany Spain Chronic kidney disease Muscle Bone Physical performance Vitamin D
ISSN:	2190-5991, 2190-6009, 2190-6009
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Zusammenfassung:	The spectrum of activity of vitamin D goes beyond calcium and bone homeostasis, and growing evidence suggests that vitamin D contributes to maintain musculoskeletal health in healthy subjects as well as in patients with chronic kidney disease (CKD), who display the combination of bone metabolism disorder, muscle wasting, and weakness. Here, we review how vitamin D represents a pathway in which bone and muscle may interact. In vitro studies have confirmed that the vitamin D receptor is present on muscle, describing the mechanisms whereby vitamin D directly affects skeletal muscle. These include genomic and non‐genomic (rapid) effects, regulating cellular differentiation and proliferation. Observational studies have shown that circulating 25‐hydroxyvitamin D levels correlate with the clinical symptoms and muscle morphological changes observed in CKD patients. Vitamin D deficiency has been linked to low bone formation rate and bone mineral density, with an increased risk of skeletal fractures. The impact of low vitamin D status on skeletal muscle may also affect muscle metabolic pathways, including its sensitivity to insulin. Although some interventional studies have shown that vitamin D may improve physical performance and protect against the development of histological and radiological signs of hyperparathyroidism, evidence is still insufficient to draw definitive conclusions.
Bibliographie:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 ObjectType-Review-3 content type line 23 Board members of the ERN and CKD‐MBD working groups are listed in the Acknowledgements
ISSN:	2190-5991 2190-6009 2190-6009
DOI:	10.1002/jcsm.12218