Evaluation of stimulated raman scattering microscopy for identifying squamous cell carcinoma in human skin
Background and Significance There is a need to develop non‐invasive diagnostic tools to achieve early and accurate detection of skin cancer in a non‐surgical manner. In this study, we evaluate the capability of stimulated Raman scattering (SRS) microscopy, a potentially non‐invasive optical imaging...
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| Vydáno v: | Lasers in surgery and medicine Ročník 45; číslo 8; s. 496 - 502 |
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| Hlavní autoři: | , , , , , , |
| Médium: | Journal Article |
| Jazyk: | angličtina |
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United States
Blackwell Publishing Ltd
01.10.2013
Wiley Subscription Services, Inc |
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| ISSN: | 0196-8092, 1096-9101, 1096-9101 |
| On-line přístup: | Získat plný text |
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| Abstract | Background and Significance
There is a need to develop non‐invasive diagnostic tools to achieve early and accurate detection of skin cancer in a non‐surgical manner. In this study, we evaluate the capability of stimulated Raman scattering (SRS) microscopy, a potentially non‐invasive optical imaging technique, for identifying the pathological features of s squamous cell carcinoma (SCC) tissue.
Study Design
We studied ex vivo SCC and healthy skin tissues using SRS microscopy, and compared the SRS contrast with the contrast obtained in reflectance confocal microscopy (RCM) and standard histology.
Results and Conclusion
SRS images obtained at the carbon‐hydrogen stretching vibration at 2945 cm−1 exhibit contrast related protein density that clearly delineates the cell nucleus from the cell cytoplasm. The morphological features of SCC tumor seen in the SRS images show excellent correlation with the diagnostic features identified by histological examination. Additionally, SRS exhibits enhanced cellular contrast in comparison to that seen in confocal microscopy. In conclusion, SRS represents an attractive approach for generating protein density maps with contrast that closely resembles histopathological contrast of SCC in human skin. Lasers Surg. Med. 45:496–502, 2013. © 2013 Wiley Periodicals, Inc. |
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| AbstractList | There is a need to develop non-invasive diagnostic tools to achieve early and accurate detection of skin cancer in a non-surgical manner. In this study, we evaluate the capability of stimulated Raman scattering (SRS) microscopy, a potentially non-invasive optical imaging technique, for identifying the pathological features of s squamous cell carcinoma (SCC) tissue.BACKGROUND AND SIGNIFICANCEThere is a need to develop non-invasive diagnostic tools to achieve early and accurate detection of skin cancer in a non-surgical manner. In this study, we evaluate the capability of stimulated Raman scattering (SRS) microscopy, a potentially non-invasive optical imaging technique, for identifying the pathological features of s squamous cell carcinoma (SCC) tissue.We studied ex vivo SCC and healthy skin tissues using SRS microscopy, and compared the SRS contrast with the contrast obtained in reflectance confocal microscopy (RCM) and standard histology.STUDY DESIGNWe studied ex vivo SCC and healthy skin tissues using SRS microscopy, and compared the SRS contrast with the contrast obtained in reflectance confocal microscopy (RCM) and standard histology.SRS images obtained at the carbon-hydrogen stretching vibration at 2945 cm(-1) exhibit contrast related protein density that clearly delineates the cell nucleus from the cell cytoplasm. The morphological features of SCC tumor seen in the SRS images show excellent correlation with the diagnostic features identified by histological examination. Additionally, SRS exhibits enhanced cellular contrast in comparison to that seen in confocal microscopy. In conclusion, SRS represents an attractive approach for generating protein density maps with contrast that closely resembles histopathological contrast of SCC in human skin.RESULTS AND CONCLUSIONSRS images obtained at the carbon-hydrogen stretching vibration at 2945 cm(-1) exhibit contrast related protein density that clearly delineates the cell nucleus from the cell cytoplasm. The morphological features of SCC tumor seen in the SRS images show excellent correlation with the diagnostic features identified by histological examination. Additionally, SRS exhibits enhanced cellular contrast in comparison to that seen in confocal microscopy. In conclusion, SRS represents an attractive approach for generating protein density maps with contrast that closely resembles histopathological contrast of SCC in human skin. Background and Significance There is a need to develop non-invasive diagnostic tools to achieve early and accurate detection of skin cancer in a non-surgical manner. In this study, we evaluate the capability of stimulated Raman scattering (SRS) microscopy, a potentially non-invasive optical imaging technique, for identifying the pathological features of s squamous cell carcinoma (SCC) tissue. Study Design We studied ex vivo SCC and healthy skin tissues using SRS microscopy, and compared the SRS contrast with the contrast obtained in reflectance confocal microscopy (RCM) and standard histology. Results and Conclusion SRS images obtained at the carbon-hydrogen stretching vibration at 2945cm super(-1) exhibit contrast related protein density that clearly delineates the cell nucleus from the cell cytoplasm. The morphological features of SCC tumor seen in the SRS images show excellent correlation with the diagnostic features identified by histological examination. Additionally, SRS exhibits enhanced cellular contrast in comparison to that seen in confocal microscopy. In conclusion, SRS represents an attractive approach for generating protein density maps with contrast that closely resembles histopathological contrast of SCC in human skin. Lasers Surg. Med. 45:496-502, 2013. [copy 2013 Wiley Periodicals, Inc. Background and Significance There is a need to develop non‐invasive diagnostic tools to achieve early and accurate detection of skin cancer in a non‐surgical manner. In this study, we evaluate the capability of stimulated Raman scattering (SRS) microscopy, a potentially non‐invasive optical imaging technique, for identifying the pathological features of s squamous cell carcinoma (SCC) tissue. Study Design We studied ex vivo SCC and healthy skin tissues using SRS microscopy, and compared the SRS contrast with the contrast obtained in reflectance confocal microscopy (RCM) and standard histology. Results and Conclusion SRS images obtained at the carbon‐hydrogen stretching vibration at 2945 cm−1 exhibit contrast related protein density that clearly delineates the cell nucleus from the cell cytoplasm. The morphological features of SCC tumor seen in the SRS images show excellent correlation with the diagnostic features identified by histological examination. Additionally, SRS exhibits enhanced cellular contrast in comparison to that seen in confocal microscopy. In conclusion, SRS represents an attractive approach for generating protein density maps with contrast that closely resembles histopathological contrast of SCC in human skin. Lasers Surg. Med. 45:496–502, 2013. © 2013 Wiley Periodicals, Inc. Background and Significance There is a need to develop non-invasive diagnostic tools to achieve early and accurate detection of skin cancer in a non-surgical manner. In this study, we evaluate the capability of stimulated Raman scattering (SRS) microscopy, a potentially non-invasive optical imaging technique, for identifying the pathological features of s squamous cell carcinoma (SCC) tissue. Study Design We studied ex vivo SCC and healthy skin tissues using SRS microscopy, and compared the SRS contrast with the contrast obtained in reflectance confocal microscopy (RCM) and standard histology. Results and Conclusion SRS images obtained at the carbon-hydrogen stretching vibration at 2945cm-1 exhibit contrast related protein density that clearly delineates the cell nucleus from the cell cytoplasm. The morphological features of SCC tumor seen in the SRS images show excellent correlation with the diagnostic features identified by histological examination. Additionally, SRS exhibits enhanced cellular contrast in comparison to that seen in confocal microscopy. In conclusion, SRS represents an attractive approach for generating protein density maps with contrast that closely resembles histopathological contrast of SCC in human skin. Lasers Surg. Med. 45:496-502, 2013. © 2013 Wiley Periodicals, Inc. [PUBLICATION ABSTRACT] There is a need to develop non-invasive diagnostic tools to achieve early and accurate detection of skin cancer in a non-surgical manner. In this study, we evaluate the capability of stimulated Raman scattering (SRS) microscopy, a potentially non-invasive optical imaging technique, for identifying the pathological features of s squamous cell carcinoma (SCC) tissue. We studied ex vivo SCC and healthy skin tissues using SRS microscopy, and compared the SRS contrast with the contrast obtained in reflectance confocal microscopy (RCM) and standard histology. SRS images obtained at the carbon-hydrogen stretching vibration at 2945 cm(-1) exhibit contrast related protein density that clearly delineates the cell nucleus from the cell cytoplasm. The morphological features of SCC tumor seen in the SRS images show excellent correlation with the diagnostic features identified by histological examination. Additionally, SRS exhibits enhanced cellular contrast in comparison to that seen in confocal microscopy. In conclusion, SRS represents an attractive approach for generating protein density maps with contrast that closely resembles histopathological contrast of SCC in human skin. |
| Author | Krasieva, Tatiana Balu, Mihaela Mittal, Richa Elkeeb, Laila Wilder-Smith, Petra Potma, Eric O. Zachary, Christopher B. |
| AuthorAffiliation | 3 Department of Chemistry, University of California, Irvine, California 92697 2 Department of Chemical Engineering and Materials Sciences, University of California, Irvine, California 92697 4 Department of Dermatology, University of California, Irvine, California 92697 1 Beckman Laser Institute and Medical Clinic, University of California, Irvine, California 92612 |
| AuthorAffiliation_xml | – name: 2 Department of Chemical Engineering and Materials Sciences, University of California, Irvine, California 92697 – name: 3 Department of Chemistry, University of California, Irvine, California 92697 – name: 4 Department of Dermatology, University of California, Irvine, California 92697 – name: 1 Beckman Laser Institute and Medical Clinic, University of California, Irvine, California 92612 |
| Author_xml | – sequence: 1 givenname: Richa surname: Mittal fullname: Mittal, Richa organization: Beckman Laser Institute and Medical Clinic, University of California, 92612, Irvine, California – sequence: 2 givenname: Mihaela surname: Balu fullname: Balu, Mihaela organization: Beckman Laser Institute and Medical Clinic, University of California, California, 92612, Irvine – sequence: 3 givenname: Tatiana surname: Krasieva fullname: Krasieva, Tatiana organization: Beckman Laser Institute and Medical Clinic, University of California, California, 92612, Irvine – sequence: 4 givenname: Eric O. surname: Potma fullname: Potma, Eric O. organization: Beckman Laser Institute and Medical Clinic, University of California, 92612, Irvine, California – sequence: 5 givenname: Laila surname: Elkeeb fullname: Elkeeb, Laila organization: Department of Dermatology, University of California, California, 92697, Irvine – sequence: 6 givenname: Christopher B. surname: Zachary fullname: Zachary, Christopher B. organization: Department of Dermatology, University of California, California, 92697, Irvine – sequence: 7 givenname: Petra surname: Wilder-Smith fullname: Wilder-Smith, Petra email: Correspondence to: Petra Wilder-Smith, DDS, PhD, Beckman Laser Institute, 1002 Health Sciences Road East, University of California, Irvine, CA 92612., pwsmith@uci.edu organization: Beckman Laser Institute and Medical Clinic, University of California, California, 92612, Irvine |
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| Keywords | skin cancer stimulated Raman scattering optical microscopy confocal reflectance microscopy squamous cell carcinoma |
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There is a need to develop non‐invasive diagnostic tools to achieve early and accurate detection of skin cancer in a non‐surgical... There is a need to develop non-invasive diagnostic tools to achieve early and accurate detection of skin cancer in a non-surgical manner. In this study, we... Background and Significance There is a need to develop non-invasive diagnostic tools to achieve early and accurate detection of skin cancer in a non-surgical... |
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| SubjectTerms | Carcinoma, Squamous Cell - pathology confocal reflectance microscopy Humans In Vitro Techniques Microscopy, Confocal optical microscopy skin cancer Skin Neoplasms - pathology Spectrum Analysis, Raman - instrumentation Spectrum Analysis, Raman - methods squamous cell carcinoma stimulated Raman scattering |
| Title | Evaluation of stimulated raman scattering microscopy for identifying squamous cell carcinoma in human skin |
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