Antecedent infections in Guillain‐Barré syndrome: a single‐center, prospective study

Objective To investigate the spectrum of antecedent infections in Chinese patients with Guillain‐Barré syndrome (GBS) and analyze the infections‐related clinical phenotypes locally. Methods A prospective case‐control study of 150 patients diagnosed with GBS and age‐ and sex‐matched neurological and...

Celý popis

Uložené v:
Podrobná bibliografia
Vydané v:Annals of clinical and translational neurology Ročník 6; číslo 12; s. 2510 - 2517
Hlavní autori: Hao, Yanlei, Wang, Weifang, Jacobs, Bart C., Qiao, Baojun, Chen, Mengshi, Liu, Daiqiang, Feng, Xungang, Wang, Yuzhong
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: United States John Wiley & Sons, Inc 01.12.2019
John Wiley and Sons Inc
Wiley
Predmet:
Age
Campylobacter
Chicken pox
Cytomegalovirus
Dengue fever
Guillain-Barre syndrome
Hepatitis
Herpes viruses
Hospitals
Immunoglobulins
Infections
Influenza
Liver
Rubella
Rural areas
Zika virus
United States > US
China
ISSN:2328-9503, 2328-9503
On-line prístup:Získať plný text
Tagy: Pridať tag
Žiadne tagy, Buďte prvý, kto otaguje tento záznam!
Popis
Shrnutí:Objective To investigate the spectrum of antecedent infections in Chinese patients with Guillain‐Barré syndrome (GBS) and analyze the infections‐related clinical phenotypes locally. Methods A prospective case‐control study of 150 patients diagnosed with GBS and age‐ and sex‐matched neurological and healthy controls was performed to investigate recent infections of 14 pathogens serologically and collect the clinical data during a follow‐up of 12 months. Results In total, 53% of patients with GBS had a positive serology for recent infection, including Campylobacter jejuni (27%), influenza A (17%) and B (16%), hepatitis A virus (5%), dengue virus (3%), cytomegalovirus (3%), Epstein–Barr virus (3%), Mycoplasma pneumoniae (2%), herpes simplex virus (2%), varicella‐zoster virus (1%), and rubella virus (1%). Serology for infections of hepatitis E virus, Haemophilus influenzae, and Zika virus was negative. There was a higher frequency of C. jejuni, influenza A, influenza B, and hepatitis A virus infections in GBS patients than both the neurological and healthy controls. C. jejuni infection was more frequent in younger GBS patients and was associated with antibodies against GM1, GalNAc‐GD1a, and GM1:galactocerebroside complex. Influenza B infection was associated with a pure motor form of GBS. Interpretation C. jejuni, influenza A, influenza B, and hepatitis A virus serve as the most common cause of antecedent infections in GBS locally. Influenza B‐related GBS may represent a pure motor phenotype. Differences in the infectious spectrum worldwide may contribute to the geographical clinical heterogeneity of GBS.
Bibliografia:This work was supported by the National Natural Science Foundation of China (81771298, 81771360, and 81301072), Shandong Province Natural Science Fund Project (ZR2017LH034), Shandong Medical and Healthy Science Technology Development Plan (2016WS0184), and the Technology boosting new and old kinetic energy conversion projects of Jining City (2017SMNS002).
Funding Information
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
content type line 23
ISSN:2328-9503
2328-9503
DOI:10.1002/acn3.50946