Stabilizer-Guided Inhibition of Protein-Protein Interactions

The discovery of novel protein–protein interaction (PPI) modulators represents one of the great molecular challenges of the modern era. PPIs can be modulated by either inhibitor or stabilizer compounds, which target different though proximal regions of the protein interface. In principle, protein–st...

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Vydáno v:	Angewandte Chemie International Edition Ročník 54; číslo 52; s. 15720 - 15724
Hlavní autoři:	Milroy, Lech-Gustav, Bartel, Maria, Henen, Morkos A., Leysen, Seppe, Adriaans, Joris M. C., Brunsveld, Luc, Landrieu, Isabelle, Ottmann, Christian
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	Weinheim WILEY-VCH Verlag 21.12.2015 WILEY‐VCH Verlag Wiley Wiley Subscription Services, Inc Wiley-VCH Verlag
Vydání:	International ed. in English
Témata:	14-3-3 Proteins - chemistry Adapter proteins Adapters Alzheimer's disease Biochemistry, Molecular Biology Chemical Sciences Chemistry Chemistry, Multidisciplinary Crystallography drug discovery Inhibitors Life Sciences Magnetic resonance spectroscopy Medicinal Chemistry Modulators Neurodegenerative diseases NMR NMR spectroscopy Nuclear magnetic resonance peptide inhibitors Physical Sciences Protein Binding Protein interaction protein-protein interactions Proteins Science & Technology Structural Biology structure-guided design Tau protein Therapeutic targets drug discovery INTERFACE PHOSPHORYLATION MICROTUBULES SMALL-MOLECULE INHIBITORS peptide inhibitors TAU BINDING protein-protein interactions structure-guided design
ISSN:	1433-7851, 1521-3773, 1521-3773
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