Roles of extracellular vesicles in the aging microenvironment and age‐related diseases

Cellular senescence is a persistently hypoproliferative state with diverse stressors in a specific aging microenvironment. Senescent cells have a double‐edged sword effect: they can be physiologically beneficial for tissue repair, organ growth, and body homeostasis, and they can be pathologically ha...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Journal of extracellular vesicles Jg. 10; H. 12; S. e12154 - n/a
Hauptverfasser: Yin, Yujia, Chen, Huihui, Wang, Yizhi, Zhang, Ludi, Wang, Xipeng
Format: Journal Article
Sprache:Englisch
Veröffentlicht: United States John Wiley & Sons, Inc 01.10.2021
John Wiley and Sons Inc
Wiley
Schlagworte:
age‐related diseases
Aging
Aging - genetics
aging microenvironment
antiaging therapy
Autophagy
Biosynthesis
Cell cycle
Cell death
Cell interactions
Cellular Senescence
Cyclin-dependent kinases
DNA damage
Extracellular vesicles
Extracellular Vesicles - metabolism
Gene expression
Homeostasis
Humans
Kinases
Metabolism
Metabolites
Microenvironments
Mitochondria
Mutation
Paracrine signalling
Phosphorylation
Proteins
Review
Senescence
Signal Transduction
age-related diseases
aging microenvironment
cellular senescence
extracellular vesicles
antiaging therapy
ISSN:2001-3078, 2001-3078
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Cellular senescence is a persistently hypoproliferative state with diverse stressors in a specific aging microenvironment. Senescent cells have a double‐edged sword effect: they can be physiologically beneficial for tissue repair, organ growth, and body homeostasis, and they can be pathologically harmful in age‐related diseases. Among the hallmarks of senescence, the SASP, especially SASP‐related extracellular vesicle (EV) signalling, plays the leading role in aging transmission via paracrine and endocrine mechanisms. EVs are successful in intercellular and interorgan communication in the aging microenvironment and age‐related diseases. They have detrimental effects on downstream targets at the levels of immunity, inflammation, gene expression, and metabolism. Furthermore, EVs obtained from different donors are also promising materials and tools for antiaging treatments and are used for regeneration and rejuvenation in cell‐free systems. Here, we describe the characteristics of cellular senescence and the aging microenvironment, concentrating on the production and function of EVs in age‐related diseases, and provide new ideas for antiaging therapy with EVs.
Bibliographie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
ObjectType-Review-3
content type line 23
ISSN:2001-3078
2001-3078
DOI:10.1002/jev2.12154