Distinct metabolic adaptation of liver circadian pathways to acute and chronic patterns of alcohol intake

Binge drinking and chronic exposure to ethanol contribute to alcoholic liver diseases (ALDs). A potential link between ALDs and circadian disruption has been observed, though how different patterns of alcohol consumption differentially impact hepatic circadian metabolism remains virtually unexplored...

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Veröffentlicht in:Proceedings of the National Academy of Sciences - PNAS Jg. 116; H. 50; S. 25250
Hauptverfasser: Gaucher, Jonathan, Kinouchi, Kenichiro, Ceglia, Nicholas, Montellier, Emilie, Peleg, Shahaf, Greco, Carolina Magdalen, Schmidt, Andreas, Forne, Ignasi, Masri, Selma, Baldi, Pierre, Imhof, Axel, Sassone-Corsi, Paolo
Format: Journal Article
Sprache:Englisch
Veröffentlicht: United States 10.12.2019
Schlagworte:
Alcohol Drinking - genetics
Alcohol Drinking - metabolism
Animals
Circadian Rhythm
Ethanol - metabolism
Humans
Liver - metabolism
Male
Mice, Inbred C57BL
Sterol Regulatory Element Binding Proteins - genetics
Sterol Regulatory Element Binding Proteins - metabolism
Transcriptome
acetylation
alcohol
circadian
metabolism
liver
ISSN:1091-6490, 1091-6490
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Zusammenfassung:Binge drinking and chronic exposure to ethanol contribute to alcoholic liver diseases (ALDs). A potential link between ALDs and circadian disruption has been observed, though how different patterns of alcohol consumption differentially impact hepatic circadian metabolism remains virtually unexplored. Using acute versus chronic ethanol feeding, we reveal differential reprogramming of the circadian transcriptome in the liver. Specifically, rewiring of diurnal SREBP transcriptional pathway leads to distinct hepatic signatures in acetyl-CoA metabolism that are translated into the subcellular patterns of protein acetylation. Thus, distinct drinking patterns of alcohol dictate differential adaptation of hepatic circadian metabolism.
Bibliographie:ObjectType-Article-1
SourceType-Scholarly Journals-1
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content type line 23
ISSN:1091-6490
1091-6490
DOI:10.1073/pnas.1911189116