Distinct metabolic adaptation of liver circadian pathways to acute and chronic patterns of alcohol intake

Binge drinking and chronic exposure to ethanol contribute to alcoholic liver diseases (ALDs). A potential link between ALDs and circadian disruption has been observed, though how different patterns of alcohol consumption differentially impact hepatic circadian metabolism remains virtually unexplored...

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Published in:Proceedings of the National Academy of Sciences - PNAS Vol. 116; no. 50; p. 25250
Main Authors: Gaucher, Jonathan, Kinouchi, Kenichiro, Ceglia, Nicholas, Montellier, Emilie, Peleg, Shahaf, Greco, Carolina Magdalen, Schmidt, Andreas, Forne, Ignasi, Masri, Selma, Baldi, Pierre, Imhof, Axel, Sassone-Corsi, Paolo
Format: Journal Article
Language:English
Published: United States 10.12.2019
Subjects:
Alcohol Drinking - genetics
Alcohol Drinking - metabolism
Animals
Circadian Rhythm
Ethanol - metabolism
Humans
Liver - metabolism
Male
Mice, Inbred C57BL
Sterol Regulatory Element Binding Proteins - genetics
Sterol Regulatory Element Binding Proteins - metabolism
Transcriptome
acetylation
alcohol
circadian
metabolism
liver
ISSN:1091-6490, 1091-6490
Online Access:Get more information
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Summary:Binge drinking and chronic exposure to ethanol contribute to alcoholic liver diseases (ALDs). A potential link between ALDs and circadian disruption has been observed, though how different patterns of alcohol consumption differentially impact hepatic circadian metabolism remains virtually unexplored. Using acute versus chronic ethanol feeding, we reveal differential reprogramming of the circadian transcriptome in the liver. Specifically, rewiring of diurnal SREBP transcriptional pathway leads to distinct hepatic signatures in acetyl-CoA metabolism that are translated into the subcellular patterns of protein acetylation. Thus, distinct drinking patterns of alcohol dictate differential adaptation of hepatic circadian metabolism.
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ISSN:1091-6490
1091-6490
DOI:10.1073/pnas.1911189116