Distinct metabolic adaptation of liver circadian pathways to acute and chronic patterns of alcohol intake

Binge drinking and chronic exposure to ethanol contribute to alcoholic liver diseases (ALDs). A potential link between ALDs and circadian disruption has been observed, though how different patterns of alcohol consumption differentially impact hepatic circadian metabolism remains virtually unexplored...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS Jg. 116; H. 50; S. 25250
Hauptverfasser:	Gaucher, Jonathan, Kinouchi, Kenichiro, Ceglia, Nicholas, Montellier, Emilie, Peleg, Shahaf, Greco, Carolina Magdalen, Schmidt, Andreas, Forne, Ignasi, Masri, Selma, Baldi, Pierre, Imhof, Axel, Sassone-Corsi, Paolo
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 10.12.2019
Schlagworte:	Alcohol Drinking - genetics Alcohol Drinking - metabolism Animals Circadian Rhythm Ethanol - metabolism Humans Liver - metabolism Male Mice, Inbred C57BL Sterol Regulatory Element Binding Proteins - genetics Sterol Regulatory Element Binding Proteins - metabolism Transcriptome acetylation alcohol circadian metabolism liver
ISSN:	1091-6490, 1091-6490
Online-Zugang:	Weitere Angaben
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