Effect of therapeutic drug monitoring-based dose optimization of piperacillin/tazobactam on sepsis-related organ dysfunction in patients with sepsis: a randomized controlled trial

Purpose Insufficient antimicrobial exposure is associated with worse outcomes in sepsis. We evaluated whether therapeutic drug monitoring (TDM)-guided antibiotic therapy improves outcomes. Methods Randomized, multicenter, controlled trial from January 2017 to December 2019. Adult patients ( n = 254...

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Bibliographic Details
Published in:	Intensive care medicine Vol. 48; no. 3; pp. 311 - 321
Main Authors:	Hagel, Stefan, Bach, Friedhelm, Brenner, Thorsten, Bracht, Hendrik, Brinkmann, Alexander, Annecke, Thorsten, Hohn, Andreas, Weigand, Markus, Michels, Guido, Kluge, Stefan, Nierhaus, Axel, Jarczak, Dominik, König, Christina, Weismann, Dirk, Frey, Otto, Witzke, Dominic, Müller, Carsten, Bauer, Michael, Kiehntopf, Michael, Neugebauer, Sophie, Lehmann, Thomas, Roberts, Jason A., Pletz, Mathias W.
Format:	Journal Article
Language:	English
Published:	Berlin/Heidelberg Springer Berlin Heidelberg 01.03.2022 Springer Springer Nature B.V
Subjects:	Adult Anesthesiology Anti-Bacterial Agents - therapeutic use Antibiotics Antiinfectives and antibacterials Care and treatment Clinical trials Critical Care Medicine Dosage Drug dosages Drug Monitoring Emergency Medicine Evaluation Female Health aspects Health care industry Humans Infection Intensive Intensive care Medicine Medicine & Public Health Monitoring Multiple Organ Failure Optimization Original Pain Medicine Patients Pediatrics Penicillanic Acid Piperacillin Piperacillin - therapeutic use Piperacillin, Tazobactam Drug Combination - therapeutic use Pneumology/Respiratory System Pseudomonas aeruginosa Sepsis Sepsis - complications Sepsis - drug therapy Septic shock Tazobactam Therapeutic drug monitoring Therapy Germany Therapeutic drug monitoring Sepsis β-Lactams
ISSN:	0342-4642, 1432-1238, 1432-1238
Online Access:	Get full text
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