Degradation of pharmaceutical compound pentoxifylline in water by non-thermal plasma treatment

The decomposition of a model pharmaceutical compound, pentoxifylline, in aqueous solution was investigated using a dielectric barrier discharge (DBD) in coaxial configuration, operated in pulsed regime, at atmospheric pressure and room temperature. The solution was made to flow as a film over the su...

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Bibliographic Details
Published in:Water research (Oxford) Vol. 44; no. 11; pp. 3445 - 3453
Main Authors: Magureanu, Monica, Piroi, Daniela, Mandache, Nicolae Bogdan, David, Victor, Medvedovici, Andrei, Parvulescu, Vasile I.
Format: Journal Article
Language:English
Published: Kidlington Elsevier Ltd 01.06.2010
Elsevier
Subjects:
Advanced oxidation process (AOP)
analysis
Applied sciences
Atmospheric pressure
chemistry
Decomposition
Degradation
Dielectric barrier discharge
Discharge
Electricity
Electrodes
Exact sciences and technology
Flow rate
Freshwater
Liquids
mass spectrometry
methods
Non-thermal plasma
Other industrial wastes. Sewage sludge
oxygen
Pentoxifylline
Pentoxifylline - analysis
Pentoxifylline - chemistry
Pharmaceutical
Pharmaceuticals
Pollution
Reactors
Temperature
Waste Disposal, Fluid
Waste Disposal, Fluid - methods
Wastes
Water Pollutants, Chemical
Water Pollutants, Chemical - analysis
Water Pollutants, Chemical - chemistry
Water treatment
Water treatment and pollution
Pentoxifylline
Water treatment
Non-thermal plasma
Pharmaceutical
Dielectric barrier discharge
Advanced oxidation process (AOP)
Gas liquid interface
Drug
Plasma reactor
Dielectric materials
Liquid chromatography
Non thermal plasma
Non equilibrium plasma
Electric discharge
Model compound
Oxidation
Degradation product
Mass spectrometry
Organic compounds
ISSN:0043-1354, 1879-2448, 1879-2448
Online Access:Get full text
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Summary:The decomposition of a model pharmaceutical compound, pentoxifylline, in aqueous solution was investigated using a dielectric barrier discharge (DBD) in coaxial configuration, operated in pulsed regime, at atmospheric pressure and room temperature. The solution was made to flow as a film over the surface of the inner electrode of the plasma reactor, so the discharge was generated at the gas–liquid interface. Oxygen was introduced with a flow rate of 600 sccm. After 60 min plasma treatment 92.5% removal of pentoxifylline was achieved and the corresponding decomposition yield was 16 g/kWh. It was found that pentoxifylline degradation depended on the initial concentration of the compound, being faster for lower concentrations. Faster decomposition of pentoxifylline could be also achieved by increasing the pulse repetition rate, and implicitly the power introduced in the discharge, however, this had little effect on the decomposition yield. The degradation products were investigated by liquid chromatography–mass spectrometry technique (LC–MS). The evolution of the intermediates during plasma treatment showed a fast increase in the first 30 min, followed by a slower decrease, so that these products are almost completely removed after 120 min treatment time.
Bibliography:http://dx.doi.org/10.1016/j.watres.2010.03.020
ObjectType-Article-1
SourceType-Scholarly Journals-1
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content type line 23
ISSN:0043-1354
1879-2448
1879-2448
DOI:10.1016/j.watres.2010.03.020