Degradation of pharmaceutical compound pentoxifylline in water by non-thermal plasma treatment

The decomposition of a model pharmaceutical compound, pentoxifylline, in aqueous solution was investigated using a dielectric barrier discharge (DBD) in coaxial configuration, operated in pulsed regime, at atmospheric pressure and room temperature. The solution was made to flow as a film over the su...

Celý popis

Uložené v:

Podrobná bibliografia
Vydané v:	Water research (Oxford) Ročník 44; číslo 11; s. 3445 - 3453
Hlavní autori:	Magureanu, Monica, Piroi, Daniela, Mandache, Nicolae Bogdan, David, Victor, Medvedovici, Andrei, Parvulescu, Vasile I.
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	Kidlington Elsevier Ltd 01.06.2010 Elsevier
Predmet:	Advanced oxidation process (AOP) analysis Applied sciences Atmospheric pressure chemistry Decomposition Degradation Dielectric barrier discharge Discharge Electricity Electrodes Exact sciences and technology Flow rate Freshwater Liquids mass spectrometry methods Non-thermal plasma Other industrial wastes. Sewage sludge oxygen Pentoxifylline Pentoxifylline - analysis Pentoxifylline - chemistry Pharmaceutical Pharmaceuticals Pollution Reactors Temperature Waste Disposal, Fluid Waste Disposal, Fluid - methods Wastes Water Pollutants, Chemical Water Pollutants, Chemical - analysis Water Pollutants, Chemical - chemistry Water treatment Water treatment and pollution Pentoxifylline Water treatment Non-thermal plasma Pharmaceutical Dielectric barrier discharge Advanced oxidation process (AOP) Gas liquid interface Drug Plasma reactor Dielectric materials Liquid chromatography Non thermal plasma Non equilibrium plasma Electric discharge Model compound Oxidation Degradation product Mass spectrometry Organic compounds
ISSN:	0043-1354, 1879-2448, 1879-2448
On-line prístup:	Získať plný text
Tagy:	Pridať tag Žiadne tagy, Buďte prvý, kto otaguje tento záznam!

Popis
Shrnutí:	The decomposition of a model pharmaceutical compound, pentoxifylline, in aqueous solution was investigated using a dielectric barrier discharge (DBD) in coaxial configuration, operated in pulsed regime, at atmospheric pressure and room temperature. The solution was made to flow as a film over the surface of the inner electrode of the plasma reactor, so the discharge was generated at the gas–liquid interface. Oxygen was introduced with a flow rate of 600 sccm. After 60 min plasma treatment 92.5% removal of pentoxifylline was achieved and the corresponding decomposition yield was 16 g/kWh. It was found that pentoxifylline degradation depended on the initial concentration of the compound, being faster for lower concentrations. Faster decomposition of pentoxifylline could be also achieved by increasing the pulse repetition rate, and implicitly the power introduced in the discharge, however, this had little effect on the decomposition yield. The degradation products were investigated by liquid chromatography–mass spectrometry technique (LC–MS). The evolution of the intermediates during plasma treatment showed a fast increase in the first 30 min, followed by a slower decrease, so that these products are almost completely removed after 120 min treatment time.
Bibliografia:	http://dx.doi.org/10.1016/j.watres.2010.03.020 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0043-1354 1879-2448 1879-2448
DOI:	10.1016/j.watres.2010.03.020