Dietary L-Cysteine Improves the Antioxidative Potential and Lipid Metabolism in Rats Fed a Normal Diet

L-Cysteine works as a precursor of the antioxidant, glutathione. We investigated the effects of L-cysteine (1% and 2%) on lipid metabolism and the antioxidative system in rats fed a normal diet. Administering L-cysteine dependently decreased the food intake, fat mass weight and body weight dose. Die...

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Published in:Bioscience, biotechnology, and biochemistry Vol. 77; no. 7; pp. 1430 - 1434
Main Authors: LEE, Seulki, HAN, Kyu-Ho, NAKAMURA, Yumi, KAWAKAMI, Sakura, SHIMADA, Ken-ichiro, HAYAKAWA, Touru, ONOUE, Hirotake, FUKUSHIMA, Michihiro
Format: Journal Article
Language:English
Published: England Japan Society for Bioscience, Biotechnology, and Agrochemistry 2013
Oxford University Press
Subjects:
Animals
antioxidant
antioxidant activity
antioxidant enzymes
Antioxidants - metabolism
biotechnology
Blood Glucose - metabolism
blood serum
body weight
Body Weight - drug effects
catalase
Chickens
cysteine
Cysteine - pharmacology
Diet
Dose-Response Relationship, Drug
Eating - drug effects
food intake
glutathione
Glutathione - metabolism
glutathione-disulfide reductase
L-cysteine
lipid metabolism
Lipid Metabolism - drug effects
Lipid Peroxidation - drug effects
liver
Liver - anatomy & histology
Liver - drug effects
Liver - metabolism
Male
Organ Size - drug effects
rat
Rats
triacylglycerols
triglyceride
Triglycerides - blood
Triglycerides - metabolism
ISSN:0916-8451, 1347-6947, 1347-6947
Online Access:Get full text
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Summary:L-Cysteine works as a precursor of the antioxidant, glutathione. We investigated the effects of L-cysteine (1% and 2%) on lipid metabolism and the antioxidative system in rats fed a normal diet. Administering L-cysteine dependently decreased the food intake, fat mass weight and body weight dose. Dietary L-cysteine also decreased the triglyceride levels in the serum and liver. However, there were no significant differences in the hepatic TBARS and glutathione (GSH) levels among the groups. The activities of catalase and glutathione reductase in the rats receiving 2% L-cysteine were significantly higher (p<0.05) than in the control rats. These results suggest that dietary L-cysteine dose-dependently affected the antioxidative enzyme activities, and the lipid levels in the serum and liver which might be related to the reduced food intake.
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ISSN:0916-8451
1347-6947
1347-6947
DOI:10.1271/bbb.130083