Pelota: A double-edged sword in virus infection

Pelota, a conserved ribosome rescue factor involved in mRNA surveillance, has emerged as a pivotal player in host–virus arms race. Beyond its canonical role in maintaining translational fidelity via No-Go Decay and Non-Stop Decay pathways, Pelota exhibits a dual function during viral infection-servi...

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Veröffentlicht in:PLoS pathogens Jg. 21; H. 7; S. e1013328
Hauptverfasser: Li, Xue, Zhou, Xueping, Li, Fangfang
Format: Journal Article
Sprache:Englisch
Veröffentlicht: United States Public Library of Science 01.07.2025
Public Library of Science (PLoS)
Schlagworte:
Analysis
Autoimmunity
Biology and Life Sciences
Cellular proteins
Chemical properties
Coevolution
Decay
Dengue fever
Disease resistance
DNA viruses
Host-Pathogen Interactions
Host-virus relationships
Identification and classification
Influence
Medicine and Health Sciences
Messenger RNA
mRNA
Mutation
Phenotypes
Plant Diseases - genetics
Plant Diseases - virology
Plant Proteins - genetics
Plant Proteins - metabolism
Plant virus diseases
Plant viruses
Propagation
Quality control
Research and Analysis Methods
Review
Ribonucleic acid
RNA
RNA viruses
SUMO protein
Tomatoes
Translation
Viral infections
Viral proteins
Virus Diseases - genetics
Virus Diseases - metabolism
Virus Diseases - virology
Viruses
Yeast
China
Indonesia
ISSN:1553-7374, 1553-7366, 1553-7374
Online-Zugang:Volltext
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Zusammenfassung:Pelota, a conserved ribosome rescue factor involved in mRNA surveillance, has emerged as a pivotal player in host–virus arms race. Beyond its canonical role in maintaining translational fidelity via No-Go Decay and Non-Stop Decay pathways, Pelota exhibits a dual function during viral infection-serving either as a restriction factor or as a susceptibility element depending on the virus species and their hosts. In DNA virus infections, notably with geminiviruses, a natural mutation in Pelota confers recessive resistance in tomato and pepper probably by impairing viral protein translation, offering valuable insights for resistance breeding. Conversely, in RNA virus infections, Pelota usually restricts viral propagation through RNA quality control, yet can also promote viral replication by facilitating ribosome recycling and translation. This paradox reflects a fine-tuned balance in host–virus adaption and co-evolution. Additionally, pelota mutations can modulate immune signaling pathways, with some alleles triggering enhanced resistance or autoimmunity phenotypes in plants. Meanwhile, viruses have evolved counterdefense strategies, including targeted degradation or SUMOylation interference, to subvert the Pelota’s function. Together, these findings position Pelota as a double-edged sword in viral infection, highlighting its potential as a novel target for antiviral strategies through precise genetic manipulation.
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The authors have declared that no competing interests exist.
ISSN:1553-7374
1553-7366
1553-7374
DOI:10.1371/journal.ppat.1013328