Pelota: A double-edged sword in virus infection

Pelota, a conserved ribosome rescue factor involved in mRNA surveillance, has emerged as a pivotal player in host–virus arms race. Beyond its canonical role in maintaining translational fidelity via No-Go Decay and Non-Stop Decay pathways, Pelota exhibits a dual function during viral infection-servi...

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Vydané v:	PLoS pathogens Ročník 21; číslo 7; s. e1013328
Hlavní autori:	Li, Xue, Zhou, Xueping, Li, Fangfang
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States Public Library of Science 01.07.2025 Public Library of Science (PLoS)
Predmet:	Analysis Autoimmunity Biology and Life Sciences Cellular proteins Chemical properties Coevolution Decay Dengue fever Disease resistance DNA viruses Host-Pathogen Interactions Host-virus relationships Identification and classification Influence Medicine and Health Sciences Messenger RNA mRNA Mutation Phenotypes Plant Diseases - genetics Plant Diseases - virology Plant Proteins - genetics Plant Proteins - metabolism Plant virus diseases Plant viruses Propagation Quality control Research and Analysis Methods Review Ribonucleic acid RNA RNA viruses SUMO protein Tomatoes Translation Viral infections Viral proteins Virus Diseases - genetics Virus Diseases - metabolism Virus Diseases - virology Viruses Yeast China Indonesia
ISSN:	1553-7374, 1553-7366, 1553-7374
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Popis
Shrnutí:	Pelota, a conserved ribosome rescue factor involved in mRNA surveillance, has emerged as a pivotal player in host–virus arms race. Beyond its canonical role in maintaining translational fidelity via No-Go Decay and Non-Stop Decay pathways, Pelota exhibits a dual function during viral infection-serving either as a restriction factor or as a susceptibility element depending on the virus species and their hosts. In DNA virus infections, notably with geminiviruses, a natural mutation in Pelota confers recessive resistance in tomato and pepper probably by impairing viral protein translation, offering valuable insights for resistance breeding. Conversely, in RNA virus infections, Pelota usually restricts viral propagation through RNA quality control, yet can also promote viral replication by facilitating ribosome recycling and translation. This paradox reflects a fine-tuned balance in host–virus adaption and co-evolution. Additionally, pelota mutations can modulate immune signaling pathways, with some alleles triggering enhanced resistance or autoimmunity phenotypes in plants. Meanwhile, viruses have evolved counterdefense strategies, including targeted degradation or SUMOylation interference, to subvert the Pelota’s function. Together, these findings position Pelota as a double-edged sword in viral infection, highlighting its potential as a novel target for antiviral strategies through precise genetic manipulation.
Bibliografia:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 ObjectType-Review-3 content type line 23 The authors have declared that no competing interests exist.
ISSN:	1553-7374 1553-7366 1553-7374
DOI:	10.1371/journal.ppat.1013328