Evaluation of epithelial mesenchymal transition in patients with chronic obstructive pulmonary disease

Background The reticular basement membrane (Rbm) in smokers and especially smokers with COPD is fragmented with "clefts" containing cells staining for the collagenase matrix-metalloproteinase-9 (MMP-9) and fibroblast protein, S100A4. These cells are also present in the basal epithelium. Su...

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Bibliographic Details
Published in:	Respiratory research Vol. 12; no. 1; p. 130
Main Authors:	Sohal, Sukhwinder S, Reid, David, Soltani, Amir, Ward, Chris, Weston, Steven, Muller, H Konrad, Wood-Baker, Richard, Walters, E Haydn
Format:	Journal Article
Language:	English
Published:	London BioMed Central 05.10.2011 BioMed Central Ltd Nature Publishing Group BMC
Subjects:	Aged Analysis Antigenic determinants B cells Care and treatment Chronic obstructive pulmonary disease clefts cytokeratin epithelial mesenchymal transition (EMT) Epithelial-Mesenchymal Transition - physiology Female Genotype & phenotype Health aspects Histology Human subjects Humans Inflammation - diagnosis Inflammation - metabolism Inflammation - pathology inflammatory cells and S100A4 Keratin Lung diseases, Obstructive Lymphocytes Male Matrix Metalloproteinase 9 - biosynthesis Medicine Medicine & Public Health Mesoderm - enzymology Mesoderm - metabolism Mesoderm - pathology Middle Aged Pneumology/Respiratory System Pulmonary Disease, Chronic Obstructive - enzymology Pulmonary Disease, Chronic Obstructive - metabolism Pulmonary Disease, Chronic Obstructive - pathology Respiratory Mucosa - enzymology Respiratory Mucosa - metabolism Respiratory Mucosa - pathology Smokers Smoking - adverse effects Smoking - metabolism Smoking - pathology Statistical analysis Stem cells T cells Australia United Kingdom epithelial mesenchymal transition (EMT) clefts inflammatory cells and S100A4 cytokeratin
ISSN:	1465-993X, 1465-9921, 1465-993X
Online Access:	Get full text
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