Mapping the serum proteome to neurological diseases using whole genome sequencing

Despite the increasing global burden of neurological disorders, there is a lack of effective diagnostic and therapeutic biomarkers. Proteins are often dysregulated in disease and have a strong genetic component. Here, we carry out a protein quantitative trait locus analysis of 184 neurologically-rel...

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Bibliographic Details
Published in:	Nature communications Vol. 12; no. 1; pp. 7042 - 12
Main Authors:	Png, Grace, Barysenka, Andrei, Repetto, Linda, Navarro, Pau, Shen, Xia, Pietzner, Maik, Wheeler, Eleanor, Wareham, Nicholas J., Langenberg, Claudia, Tsafantakis, Emmanouil, Karaleftheri, Maria, Dedoussis, George, Mälarstig, Anders, Wilson, James F., Gilly, Arthur, Zeggini, Eleftheria
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 02.12.2021 Nature Publishing Group Nature Portfolio
Subjects:	45 45/23 45/43 631/208/205/2138 631/208/366 692/53/2423 692/699/375 82/1 82/80 Alzheimer Disease - blood Alzheimer Disease - diagnosis Alzheimer Disease - genetics Alzheimer Disease - pathology Alzheimer's disease Biomarkers Biomarkers - blood Cohort Studies Gene Expression Gene mapping Gene Ontology Gene sequencing Genetic Predisposition to Disease Genome, Human Genomes Humanities and Social Sciences Humans Membrane Glycoproteins - blood Membrane Glycoproteins - genetics Mendelian Randomization Analysis Mental disorders Molecular Sequence Annotation Movement disorders multidisciplinary Neurodegenerative diseases Neurological diseases Neurological disorders Parkinson Disease - blood Parkinson Disease - diagnosis Parkinson Disease - genetics Parkinson Disease - pathology Parkinson's disease Proteins Proteome - genetics Proteome - metabolism Proteomes Quantitative Trait Loci Scavenger Receptors, Class A - blood Scavenger Receptors, Class A - genetics Schizophrenia Schizophrenia - blood Schizophrenia - diagnosis Schizophrenia - genetics Schizophrenia - pathology Science Science (multidisciplinary) Serum proteins Sialic Acid Binding Ig-like Lectin 3 - blood Sialic Acid Binding Ig-like Lectin 3 - genetics Therapeutic targets Whole Genome Sequencing
ISSN:	2041-1723, 2041-1723
Online Access:	Get full text
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