High throughput isolation and glycosylation analysis of IgG-variability and heritability of the IgG glycome in three isolated human populations

All immunoglobulin G molecules carry N-glycans, which modulate their biological activity. Changes in N-glycosylation of IgG associate with various diseases and affect the activity of therapeutic antibodies and intravenous immunoglobulins. We have developed a novel 96-well protein G monolithic plate...

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Veröffentlicht in:	Molecular & cellular proteomics Jg. 10; H. 10; S. M111.010090
Hauptverfasser:	Pucić, Maja, Knezević, Ana, Vidic, Jana, Adamczyk, Barbara, Novokmet, Mislav, Polasek, Ozren, Gornik, Olga, Supraha-Goreta, Sandra, Wormald, Mark R, Redzić, Irma, Campbell, Harry, Wright, Alan, Hastie, Nicholas D, Wilson, James F, Rudan, Igor, Wuhrer, Manfred, Rudd, Pauline M, Josić, Djuro, Lauc, Gordan
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 01.10.2011
Schlagworte:	Adolescent Adult Aged Aged, 80 and over Female Fucose - metabolism Genetic Variation Glycomics - methods Glycoproteins - chemistry Glycoproteins - genetics Glycoproteins - isolation & purification Glycosylation High-Throughput Screening Assays Humans Immunoglobulin G - chemistry Immunoglobulin G - genetics Immunoglobulin G - isolation & purification Male Middle Aged Models, Molecular ortho-Aminobenzoates - chemistry Peptide-N4-(N-acetyl-beta-glucosaminyl) Asparagine Amidase - chemistry Polysaccharides - chemistry Population
ISSN:	1535-9484, 1535-9484
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