Protective role of fructokinase blockade in the pathogenesis of acute kidney injury in mice

Acute kidney injury is associated with high mortality, especially in intensive care unit patients. The polyol pathway is a metabolic route able to convert glucose into fructose. Here we show the detrimental role of endogenous fructose production by the polyol pathway and its metabolism through fruct...

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Veröffentlicht in:	Nature communications Jg. 8; H. 1; S. 14181 - 12
Hauptverfasser:	Andres-Hernando, Ana, Li, Nanxing, Cicerchi, Christina, Inaba, Shinichiro, Chen, Wei, Roncal-Jimenez, Carlos, Le, Myphuong T., Wempe, Michael F., Milagres, Tamara, Ishimoto, Takuji, Fini, Mehdi, Nakagawa, Takahiko, Johnson, Richard J., Lanaspa, Miguel A.
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	London Nature Publishing Group UK 13.02.2017 Nature Publishing Group Nature Portfolio
Schlagworte:	42 42/35 631/443/272 64/60 692/4022/1585/4 82 82/51 82/80 96/106 96/21 Acute Kidney Injury - etiology Acute Kidney Injury - metabolism Acute Kidney Injury - prevention & control Aldehyde Reductase - metabolism Animals Cell Line Creatinine Fructokinases - antagonists & inhibitors Fructokinases - genetics Fructokinases - metabolism Fructose - metabolism Fructose - urine Human subjects Humanities and Social Sciences Humans Intensive care Ischemia Ischemia - complications Kidney - drug effects Kidney - metabolism Kidney - pathology Kidneys Luteolin - pharmacology Metabolism Mice, Inbred C57BL Mice, Knockout multidisciplinary Oxidative stress Oxidative Stress - drug effects Pathogenesis Protective Agents - pharmacology Science Science (multidisciplinary) Surgery Uric acid Uric Acid - metabolism
ISSN:	2041-1723, 2041-1723
Online-Zugang:	Volltext
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