Nanosized bioceramic particles could function as efficient gene delivery vehicles with target specificity for the spleen

We have compared the ability of several nanosized bioceramic particles including negatively charged silica (SiO 2 ), neutrally charged hydroxyapatite (HA) and positively charged zirconia (ZrO 2 ) nanoparticles as non-viral vectors for efficient in vivo gene delivery. A mixture of highly monodisperse...

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Bibliographic Details
Published in:	Gene therapy Vol. 14; no. 10; pp. 828 - 835
Main Authors:	Tan, K, Cheang, P, Ho, I A W, Lam, P Y P, Hui, K M
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 01.05.2007 Nature Publishing Group
Subjects:	Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Animals Applied cell therapy and gene therapy Biocompatible Materials Biological and medical sciences Biological assay Biomedical and Life Sciences Biomedicine Biotechnology Cell Biology Cell Line, Tumor Ceramics in medicine Deoxyribonucleic acid DNA Female Fundamental and applied biological sciences. Psychology Gene Expression Gene Therapy Gene transfer Genetic Therapy - methods Health aspects Health. Pharmaceutical industry Human Genetics Humans Hydroxyapatite Immune response Industrial applications and implications. Economical aspects Injection Interferon-gamma - blood Interleukin 2 Interleukin-2 - blood Liposomes Luciferases - genetics Medical sciences Melanoma, Experimental Membrane Proteins - blood Methods Mice Mice, Inbred BALB C Microscopy, Confocal Microscopy, Electron Nanoparticles Nanotechnology Neoplasms - immunology Neoplasms - metabolism Neoplasms - therapy original-article Protamine sulfate Silicon dioxide Spleen Spleen - metabolism Transfection Transfection - methods Transfusions. Complications. Transfusion reactions. Cell and gene therapy Tumor cells Zirconia γ-Interferon Singapore tumor-specific immune responses nanoplexes spleen nano-bioceramics particles silica non-viral vector Particle Spleen Specificity Immune response Tumor Gene therapy Vector
ISSN:	0969-7128, 1476-5462
Online Access:	Get full text
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